Concomitant Increase of OX40 and FOXP3 Transcripts in Peripheral Blood of Patients with Breast Cancer

نویسندگان

  • Abdolhassan Talaiezadeh Department of Surgery, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz
  • Ali Khodadadi Department of Immunology and Cancer Research Center
  • Ghasem Solgi Department of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  • Maryam Hamidinia Department of Immunology and Cancer Research Center
  • Maryam Taghdiri Department of Immunology and Cancer Research Center
  • Mehri Ghafourian Boroujernia Department of Immunology, Faculty of Medicine
چکیده مقاله:

Background: Regulatory T cells (T-regs) have an important role in cancer by suppression of protective antitumor immune responses. Regulatory T cells express the forkhead/winged helix transcription factor (FOXP3) and OX40 molecules which have important regulatory roles in the immune system. Objective: To evaluate FOXP3 and OX40 transcripts in the peripheral blood mononuclear cells of women with breast cancer. Methods: Blood samples from 40 women with histologically-confirmed infiltrating ductal carcinoma of the breast and 40 healthy volunteer women without a history of malignancy or autoimmune disorders were collected. The abundance of FOXP3 and OX40 gene transcripts were determined by quantitative real-time PCR (qRT-PCR). Results: There was a significant positive correlation between FOXP3 and OX40 gene expression in women with breast cancer in a stage dependent manner. Conclusion: This finding emphasizes the importance of T-regs as predominant targets for breast cancer immunotherapy.

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concomitant increase of ox40 and foxp3 transcripts in peripheral blood of patients with breast cancer

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عنوان ژورنال

دوره 10  شماره 1

صفحات  22- 30

تاریخ انتشار 2013-03-01

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