The Effect High-Intensity Interval Training on FGF-21 Expression in Flexor Hallucis Longus Muscle and Serum TNF-α Levels in Diabetic Rats

Introduction:Type 2 diabetes is a common and prevalent metabolic disorder in the world. Metabolic pattern imbalance, insulin resistance, and increased levels of inflammatory markers in diabetic patients. Increasing myokines to exercise can be effective in regulating metabolic and inflammatory processes. The aim of this study was to investigate the effect of 6 weeks of High-Intensity Interval Training on FGF-21 Expression in  Flexor Hallucis Longus muscle tand serum TNF-α Levels of diabetic rats. Materials and Methods: In this experimental study, 48 Wistar male rats were randomly divided into 4 groups of  Diabetes and Training, Diabete+Training and Control.The training protocol was on the treadmill with increasing speed and incline for 6 weeks. At the end of the sixth week, the expression of the FGF-21 gene was measured by Real Time PCR after extracting the sample. Data were analyzed by one-way ANOVA at a significant level (p <0.05). Results: The results showed that 6 weeks of intense periodic exercise did not have a significant effect on FGF-21 gene expression of FHL muscle in diabetic rats. While reducing inflammation and inflammatory factors such as TNF-α due to High-Intensity Interval Training. Conclusion: High-Intensity Interval Training reduce inflammation and inhibit muscle weakening. exercise can be used as a therapeutic approach to managing diabetes.