The Effect of Terazocin and Prednislone in the Expulsion Therapy for Symptomatic Distal Urethral Stones

Background & Aims: [alpha]1-Adrenergic blockers have recently been shown to increase the rate of spontaneous passage of distal urethral stones. In this study the clinical role of Terazocin and Prednisolone in expulsion therapy of symptomatic distal urethral stones was assessed. Methods: The total number of 106 patients between 20-68 years old (Mean 39.05 years) who had lower ureteral stones with size of 5-10mm were selected in this prospective study. The patients were randomly divided into 2 equal groups; treatment group received Terazocin (5mg daily) plus Prednisolone (5mg daily), and control group received only analgesics. Hydration was recommended simultaneously. The treatment duration considered for 10 days to prevent the side effects resulting from prolonged corticosteroid therapy. Results: Two groups had no significant difference based on age, sex and stone location. In treatment group mean stone diameter was 7.45±1.705mm and in control group it was 6.7±1.75mm. The rate of expulsion for the treatment and control groups were 62.3% and 37.7% respectively that showes a significant difference between two groups (P<0.001). In the treatment group the number of pain episodes and analgesic (Morphin) intake was found to be lower compared to the control group. Conclusion: Simultaneous administration of terazosin ([alpha] 1-Adrenergic blocker) and Prednisolone (corticosteroid) can increase the frequency of spontaneous passage of distal urethral stones.