Mehrdad Hamidi
Department of Pharmaceutics, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, I.R. IRAN
[ 1 ] - A Quick and Sensitive Liquid Chromatography-Tandem Mass Spectrometry (LC-MS) Method for the Evaluation of Two Formulations of Amlodipine and Atorvastatin in Healthy Male Volunteers
An open-label, single-dose, randomized, 2-way crossover study was conducted in fasted healthy Iranian male volunteers. Eligible participants randomly assigned in a 1:1 ratio to be given one tablet of the test or reference formulation, followed by a 2-week washout period and administration of the exchange formulation. A quick and susceptible Liquid Chromatography–tandem Mass Spectro...
[ 2 ] - Simultaneous diagnosis and drug delivery by silymarin-loaded magnetic nanoparticles
Objective(s): The aim of this work was to prepare and characterize magnetic nanoparticles (MNPs) as theranostic system to act simultaneously as drug carrier and MRI contrast agent. Chitosan-coated MNPs (CMNPs) were prepared and loaded with silymarin. Silymarin-loaded CMNPs were characterized with various techniques and their potential as MRI contrast agent was also evaluated. Materials and Meth...
[ 3 ] - The use of Gold nanorods conjugated with Herceptin in breast cancer treatment by photothermal therapy method in mouse model
Treatment methods for breast cancer are not specific and each one has its own drawbacks. For this reason, scientists are seeking ways in which specifically affect cancer cells. Photothermal therapy is a method that uses near-infrared (NIR) laser energy to create sufficient heat to destroy cancer cells. In this study, the photothermal effect of gold nanorods (GNRs) was investigated for breast ca...
[ 4 ] - Pharmacokinetics and Bioequivalence study of Two Formulations of Cefixime in Healthy Male Volunteers
Cefixime is a significant member of orally active third generation cephalosporin and has excellent activity against many pathogens. The virtual bioavailability of a newly industrial dispersible tablet as compared with a recognized identified formulation. An open-label, single-dose, randomized, 2-way crossover study was conducted in fasted healthy Iranian male volunteers. Eligible participa...
[ 5 ] - A quick and Sensitive Liquid Chromatography–tandem Mass Spectrometry (LC-MS) Method for the Determination of Enalapril and Enalaprilat in Human Plasma: Application to a Bioequivalence Study
A rapid and sensitive liquid chromatography–tandem mass spectrometry (LC-MS) method for the estimation of enalapril and enalaprilat in human plasma. Detection of analytes was achieved by tandem mass spectrometry with electrospray ionization (ESI) interface in positive ion mode was operated under the multiple-reaction monitoring mode. Sample pretreatment involved in a one-step protein precipitat...
[ 6 ] - The use of Gold nanorods conjugated with Herceptin in breast cancer treatment by photothermal therapy method in mouse model
Treatment methods for breast cancer are not specific and each one has its own drawbacks. For this reason, scientists are seeking ways in which specifically affect cancer cells. Photothermal therapy is a method that uses near-infrared (NIR) laser energy to create sufficient heat to destroy cancer cells. In this study, the photothermal effect of gold nanorods (GNRs) was investigated for breast ca...
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