Amir Hooshang Mohammadpour
Department of Clinical Pharmacy and Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Science, Mashhad, Iran
[ 1 ] - Curcumin: Reintroduced Therapeutic Agent from Traditional Medicine for Alcoholic Liver Disease
Alcoholic liver disease (ALD) is the main cause of chronic liver disease across the world and can lead to fibrosis and cirrhosis. The etiopathogenesis of ALD is related to ethanol-induced oxidative stress, glutathione reduction, abnormal methionine metabolism, malnutrition, and production of endotoxins that activate Kupffer cells. Curcumin is an active ingredient of the rhizome of turmeric. The...
[ 2 ] - The effect of hydro-alcoholic extract of Achillea millefolium on appetite hormone in rats
Objective: Achillea millefolium (A. millefolium) is known as an orexigenic herb in Iranian traditional medicine. In this study, the possible orexigenic effect of hydro-alcoholic extract of A. millefolium was investigated by measuring plasma ghrelin level.Materials and Methods: Thirty male Wistar rats were divided into five groups. Control group received water. Treatment groups received 50, 100 ...
[ 3 ] - The effect of nano-curcumin on HbA1c, fasting blood glucose, and lipid profile in diabetic subjects: a randomized clinical trial
Objective: Diabetes mellitus is defined as a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both or insulin resistance. Curcumin inhibits NF-κB signaling pathway. The aim of this study is evaluation of the effect of Nano-curcumin on HbA1C, fast blood glucose and lipid profile in diabetic patients. Materials and Methods:...
[ 4 ] - Evaluation of Curcumin Effects on Post-Operative Peritoneal Adhesion in Rats
Objective(s)The purpose of this study holds, for the first time, an evaluation of the intraperitoneal curcumin lavage on the development of post-operative intra-abdominal adhesions.Materials and MethodsThirty male Wistar rats were randomized into five groups. The rats were administered anesthesia and underwent surgery in order to create intra-abdominal adhesions. Before the abdomen was closed, ...
[ 5 ] - Relationship between Patient Demographic Characteristics, Valproic Acid Dosage and Clearance in Adult Iranian Patients
Objective(s) As there are conflicting findings regarding the clearance-dose and patient characteristics relationships for valproic acid (VPA), this study was conducted to investigate the relationship between patient demographic characteristics, VPA dosage and the drug clearance in adult Iranian patients. Materials and Methods Patients (N= 47) were either on monotherapy with VPA or were under co...
[ 6 ] - Effect of Erythropoietin on Serum Brain-derived Biomarkers after Carbon Monoxide Poisoning in Rats
Objective(s) Erythropoietin has been shown to exert neuroprotective effects in a variety of CNS injury models. Elevation of serum S100β, as a glial damage marker and myelin basic protein (MBP) has been reported to occur in acute carbon monoxide (CO) poisoning. The aim of this study was to evaluate the effect of erythropoietin (EPO) on serum S100β and MBP levels after CO poisoning in rats. Mat...
[ 7 ] - A Review on Therapeutic Drug Monitoring of Immunosuppressant Drugs
Immunosuppressants require therapeutic drug monitoring because of their narrow therapeutic index and significant inter-individual variability in blood concentrations. This variability can be because of factors like drug-nutrient interactions, drug-disease interactions, renal-insufficiency, inflammation and infection, gender, age, polymorphism and liver mass. Drug monitoring is widely practiced ...
[ 8 ] - Comparison of Valproic acid Clearance between Epileptic Patients and Patients with Acute Mania
Objective(s) The purpose of this study was assessment of the influence of acute manic phase on the steady state pharmacokinetics of valproic acid (VPA) in bipolar patients in comparison with those of epileptic patients. Materials and Methods Ninteen acutely manic and 25 epileptic patients who fulfilled inclusion and exclusion criteria were entered in this prospective study. Blood samples were...
[ 9 ] - Therapeutic Drug Monitoring of Valproic Acid in Patients with Monotherapy at Steady State
Objective(s) The role of therapeutic drug monitoring (TDM) in patient care has grown rapidly since its introduction three decades ago. The aim of present study was to evaluate the possible relationship between serum levels and the clinical response of valproic acid (VPA). Materials and Methods In the present study we evaluated a homogeneous group of adult patients receiving VPA monotherapy. ...
[ 10 ] - Efficacy of Supportive Therapy of Allergic Rhinitis by Stinging Nettle (Urtica dioica) root extract: a randomized, double-blind, placebo-controlled clinical trial
In this study, we aimed at studying the benefit of Urtica dioica root extract in the management of allergic rhinitis. In a randomized double blind clinical trial, 74 patients with the signs and symptoms of allergic rhinitis and a positive skin prick test were randomly divided into 2 groups. The study group was treated with routine allergic rhinitis treatment and Nettle root extract (Urtidin®, B...
[ 11 ] - The Effect of Curcumin on some of Traditional and Non-traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-blind, Placebo-controlled Trial
The Effect of Curcumin on Some of Traditional and Non-Traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-Blind, Placebo-Controlled Trial Abstract Numerous interventional studies in clinical and preclinical setting stated that intake of curcumin may provide protection against cardiovascular disease. The aim of this trial was investigation of curcumin efficiency on some cardiovas...
[ 12 ] - Elevated Vancomycin Trough Concentration: Increased Efficacy and/or Toxicity?
Vancomycin susceptibility of methicillin-resistant Staphylococcus aureus has been changed over time and its average minimum inhibitory concentration increased from 1.5 to 1.75 mg/L. A recently published guideline by the American Society of Health Pharmacist recommended a daily dose of 15-20 mg/kg every 8 to 12 hours of vancomycin to achieve a trough concentration between 15-20 mg/L for treatmen...
[ 13 ] - Evaluation of Fenugreek (Trigonella foenum-graceum L.), Effects Seeds Extract on Insulin Resistance in Women with Polycystic Ovarian Syndrome
PCOS (Polycystic Ovarian Syndrome) is associated with insulin resistance, obesity and disorders of lipid metabolism as well as infertility. Fenugreek seeds extract is successfully used in lowering blood glucose. Metformin has also the same effect but in a different way. The aim of this study was the assessment of fenugreek effects on insulin resistance in women with PCOS.This was a prospective ...
[ 14 ] - Effects of Erythropoietin on Electrocardiogram Changes in Carbon Monoxide Poisoning: an Experimental Study in Rats
The aim of this study was to define the electrocardiogram (ECG) changes following the moderate to severe CO intoxication in rats, and also evaluating the effect of erythropoietin (EPO) on observed cardiac disturbances. The growing literature on erythropoietin effect on cardiac ischemia led us to question its effect on cardiotoxicity due to the carbon monoxide poisoning. Wistar rats were exposed...
[ 15 ] - Antioxidant Activity of Pistacia vera Fruits, Leaves and Gum Extracts
The side effects of synthetic antioxidants have been considered in different studies. Accordingly, there is an increasing interest toward the use of natural substances instead of the synthetic ones. In this study, the aqueous and ethanolic extracts of Pistacia vera leaves and fruits as well as hydroalcoholic extract of gum were tested for a possible antioxidant activity using in vitro methods. ...
[ 16 ] - Efficacy of Supportive Therapy of Allergic Rhinitis by Stinging Nettle (Urtica dioica) root extract: a randomized, double-blind, placebo-controlled clinical trial
In this study, we aimed at studying the benefit of Urtica dioica root extract in the management of allergic rhinitis. In a randomized double blind clinical trial, 74 patients with the signs and symptoms of allergic rhinitis and a positive skin prick test were randomly divided into 2 groups. The study group was treated with routine allergic rhinitis treatment and Nettle root extract (Urtidin®, B...
[ 17 ] - The Effect of Curcumin on some of Traditional and Non-traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-blind, Placebo-controlled Trial
The Effect of Curcumin on Some of Traditional and Non-Traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-Blind, Placebo-Controlled Trial Abstract Numerous interventional studies in clinical and preclinical setting stated that intake of curcumin may provide protection against cardiovascular disease. The aim of this trial was investigation of curcumin efficiency on some cardiovas...
[ 18 ] - Elevated Vancomycin Trough Concentration: Increased Efficacy and/or Toxicity?
Vancomycin susceptibility of methicillin-resistant Staphylococcus aureus has been changed over time and its average minimum inhibitory concentration increased from 1.5 to 1.75 mg/L. A recently published guideline by the American Society of Health Pharmacist recommended a daily dose of 15-20 mg/kg every 8 to 12 hours of vancomycin to achieve a trough concentration between 15-20 mg/L for treatmen...
[ 19 ] - Evaluation of Fenugreek (Trigonella foenum-graceum L.), Effects Seeds Extract on Insulin Resistance in Women with Polycystic Ovarian Syndrome
PCOS (Polycystic Ovarian Syndrome) is associated with insulin resistance, obesity and disorders of lipid metabolism as well as infertility. Fenugreek seeds extract is successfully used in lowering blood glucose. Metformin has also the same effect but in a different way. The aim of this study was the assessment of fenugreek effects on insulin resistance in women with PCOS.This was a prospective ...
[ 20 ] - Effects of Erythropoietin on Electrocardiogram Changes in Carbon Monoxide Poisoning: an Experimental Study in Rats
The aim of this study was to define the electrocardiogram (ECG) changes following the moderate to severe CO intoxication in rats, and also evaluating the effect of erythropoietin (EPO) on observed cardiac disturbances. The growing literature on erythropoietin effect on cardiac ischemia led us to question its effect on cardiotoxicity due to the carbon monoxide poisoning. Wistar rats were exposed...
[ 21 ] - Antioxidant Activity of Pistacia vera Fruits, Leaves and Gum Extracts
The side effects of synthetic antioxidants have been considered in different studies. Accordingly, there is an increasing interest toward the use of natural substances instead of the synthetic ones. In this study, the aqueous and ethanolic extracts of Pistacia vera leaves and fruits as well as hydroalcoholic extract of gum were tested for a possible antioxidant activity using in vitro methods. ...
[ 22 ] - The effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina: A randomized clinical trial
Objective: Inflammation along with oxidative stress has an important role in the pathophysiology of unstable angina which leads to acute myocardial infarction, arrhythmias and eventually heart failure. Curcumin has anti-inflammatory and anti-oxidant effects and thereby, it may reduce cardiovascular complications. This randomized controlled trial aimed to investigate the effects of curcumin on t...
[ 23 ] - Response to Letter to the Editor: "Evaluate the effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina"
Dear editor Regarding the duration of supplement therapy in our study which has been published in the Avicenna J Phytomed, 2019; 9(1): 1-9, “The effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina” (Dastani et al., 2019), some critical flaws has been mentioned. Primarily, we are grateful for the consi...
[ 24 ] - Evaluating the Effectiveness of Adding N-acetylcysteine to the Risperidone Treatment Regimen in Patients With Autism Disorders
Introduction: Autism spectrum disorder (ASD) has been defined as a group of neurodevelopmental disorders with variable degrees of behavioral and mental problems. Although there is no definite treatment for ASD, antipsychotics are among the available treatments. Recent clinical trials are evaluating the effectiveness of combination therapy of antipsychotics and other drugs, including N-acetylcys...
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