objective(s): the aim of the present study is to determine the effect of chloramphenicol (cap) on rat liver and small intestine. effect of phenobarbital (pb) on cap toxicity was also investigated.   materials and methods:   rats were received cap at doses of 0, 200, 400 and 600 mg/kg. another group was pretreated with 80 mg/kg pb 30 min prior to administration of various doses of cap. the exper...

background: nonalcoholic steatohepatitis (nash), a progressive stage of nonalcoholic fatty liver disease (nafld), is characterized by steatosis with inflammation. investigations have suggested that oxidative stress may play an important role in the progress of nafld to nash. to provide further insights into beneficial effects of antioxidants in nash prevention, we employed two manganese-superox...

conclusions use of ha in an algorithm model, is an extra and valuable tool for assessing liver necro inflammatory injuries- in parallel with liver biopsy- but more comprehensive studies are needed to approve the use of ha as an appropriate clinical tool. results there are several scientific studies indicating ha as a biomarker for high score fibrosis and cirrhosis in various liver diseases alon...

thyroid hormones regulate the metabolisms of all cells including hepatocytes, and hence, modulate hepatic function. hyperthyroidism is one of the most common endocrine disorders characterized by increased secretion of thyroid hormones t3 and/or t4. this study investigated frequency of abnormal liver function tests in the patients with hyperthyroidism that referred to imam reza hospital of kerma...

abstract alvelolar hydatid disease is caused by e. multilocularis. human infection occurs at the larval stage of this small tape worm (1.2 to 4.5 mm). in this article we studied alveolar hydatid disease in a 50 year old woman who presented with a hepatic mass. liver biopsy and histopathologic evaluation showed alvelolar hydatidosis of the liver. then resection of the left lobe of liver was done...

conclusions our data showed that inhalation of diazinon during pregnancy increased the hepatocyte area and hepatocyte apoptosis while it decreased the sinusoid area of the fetal liver. materials and methods twenty-five pregnant balb/c mice (25 - 30 gr) were divided into five equal groups in the animal lab of baqiyatallah university of medical sciences, tehran, iran. the normal group was without...

a three-fold decrease of the in vitro ability of serum proteins to bind naproxen was shown in patients with cirrhosis of the liver compared to healthy individuals. this decrease was caused by quantitative changes in serum proteins in the sera of patients with liver damage. lower doses of naproxen are therefore suggested in the treatment of patients with liver dysfunction.

introduction: non-alcoholic fatty liver is one of the most prevalent digestive diseases in the world and its prevalence is increasing rapidly. the objective of this study was to compare the treatment effect of pioglitazone and metformin on fatty liver. materials and methods: this double blinded clinical trial study was performed in 2012 among patients referring to gastrointestinal clinics in th...