Informative parameters of normalized electrograms the brain cats under action regulatory neuropeptides with nootropic properties were established using example Semax drug. The results obtained confirmed by a comparative pharmaco-EEG analysis various pharmacological agents directed action. pronounced stable activating and effects this group in are distinguished unidirectional that coincides data...

INTRODUCTION AND OBJECTIVE Everolimus (a drug from the class of mammalian target of rapamycin [mTOR] inhibitors) is associated with frequent toxicity-related dose reductions. Everolimus accumulates in erythrocytes, but the extent to which hematocrit affects everolimus plasma pharmacokinetics and pharmacodynamics is unknown. We aimed to investigate the everolimus pharmacokinetics/pharmacodynamic...