background: human cornea expresses functional fas-ligand capable of killing fas+ activated lymphocytes. fas expression is partly regulated by -670 a/g polymorphism in the promoter region of fas gene. objective: the aim of the present study is to determine the association between fas-670a/g polymorphism and survival of corneal transplantation. methods: in 276 graft recipients who mainly underwen...

conclusions il6 and il8 gene polymorphisms have no role in nash pathogenesis and liver fibrosis process, but presence of the a/a genotype in the il8 gene is associated with disease progression. patients and methods consecutive patients with biopsy proven nash and age- and gender-matched healthy individuals with normal liver function tests and normal ultrasonography were enrolled in the study. h...

the aim of this study was to analyze 22 cytokine polymorphisms in the roma population from the republic of macedonia. the roma population consists of 77 healthy unrelated individuals, residents of different geographical regions of the republic of macedonia (skopje, gostivar, and kochani). blood samples were collected after obtaining written consent. dna was isolated from peripheral blood and 22...

background: polymorphisms in the immune related genes are important in the clinical outcome of helicobacter pylori infection. myeloperoxidase -463 g/a polymorphism has been shown to reduce enzyme expression and activity. objective: the aim of the present study is to investigate the association of myeloperoxidase g-463a polymor-phism with clinical outcome of helicobacter pylori infection. method...

objective: to determine the possible association between the m235t variant of angiotensinogen gene and preeclampsia in iranian preeclamtic women with hypertension during pregnancy. mand methods: during a case control study, we used polymerase chain reaction-based restriction fragment length polymorphism (pcr-rflp) analysis to investigate the association between m235t polymorphism in preeclamtic...

Abstract Tuberculosis and diabetes mellitus are the most important reasons in mortality all over the world. It’s clear that reviewing of relationship between Tuberculosis (TB) and diabetes mellitus (DM) is necessary; on the other hand it’s found that FTO gene has the positive relationship with metabolic issues. Therefore, it’s necessary pay attention to the above and danger...

This study aims to investigate CYP2C19 gene polymorphisms and the association between with cardiovascular risk factors major adverse events (MACE) in patients acute myocardial infarction (AMI). A prospective cross-sectional analysis involved 86 AMI enrolled assessed MACE evaluated after three months of treatment. CYP2C19*1*1 genotype accounted for highest prevalence at 54.7%, which means normal...

Background: Follicle stimulating hormone (FSH) receptor plays an important role in FSH signaling during reproductive development. Any changes in FSHR gene is resulted in alteration of amino acid in protein chain, consequence to affect the binding affinity, intracellular signaling and expression levels of FSHR. FSHR polymorphisms can be involved in etiology of many reproductive disorders such as...