OBJECTIVE To examine the interaction between synovial fibroblasts and macrophages in the context of cartilage degradation. METHODS An in vitro model of human cartilage degradation was used, in which purified populations of fibroblasts and macrophages were added to a radiolabeled cartilage disc. Cartilage destruction was measured by the percentage of radiolabel release. RESULTS Fibroblasts, ...

The successful non-invasive imaging of articular cartilage in the equine patient is likely one of the most sought after goals in equine veterinary medicine. Articular cartilage may be one of the most difficult tissues to accurately image in its entirety in the in vivo horse. Magnetic Resonance Imaging has proven extremely useful for the successful imaging of articular cartilage in humans. For t...

objective(s) studies have shown that morphine, in addition to its analgesic properties, has several effects on cell proliferation and apoptosis. there is also evidence that opioid receptors are present on chondrocytes. our main objective in the present study was to investigate the effects of morphine on rat femur growth cartilage. materials and methods this research was carried out on 18 4-week...

Background: Cell-based treatment approach using differentiated mesenchymal stem cells (MSCs) and mature chondrocytes has been considered as an advanced treatment for cartilage repair. We investigated the differentiated level of these two cell types that is crucial for their repair capacity for cartilage defect at a co-culture micro mass system. Methods: Passaged-2 MSCs isolated from the mouse b...

most studies regarding the marrow-derived equine mesenchymal stem cells (mscs) have mainly focusedon the cell transplantation without considering the capacity of differentiation and in vitro requirements of thecells. these concerns were investigated in the present study. equine mscs were isolated from the sternalmarrow aspirates and expanded through two successive subcultures. passage-2 equine ...

background: the purpose of this study was to create biomaterial scaffolds like platelet-rich plasma (prp) and platelet-rich fibrin (prf) containing stromal cell-derived factor-1 (sdf1) as a chemokine to induce hyaline cartilage regeneration of rabbit knee in a full thickness defect. methods: we created a full thickness defect in the trochlear groove of thirty-six bilateral knees of eighteen mat...

hyaline cartilage is a vascular and neural tissue with scanty chondrocytes and limited regenerative ability. after some serious injuries of the cartilage, healing process will take place through the formation of fibrocartilage structures. currently, tissue engineering and cell therapy are 2 interesting therapeutic fields dealing with regenerative medicine. in this regard, tissue regeneration ha...

The cartilage is a connective tissue that, due to the strength of its extracellular matrix, allows the tissue to tolerate mechanical stress without undergoing permanent deformation. It is responsible for the support of soft tissues and due to its smooth surface and elasticity, gives the joints the ability to slip and bend. excessive weight, excessive activity, or trauma can all cause cartilage ...