The infiltration of dilute epinephrine solution has been used for many years to provide hemostasis. However, epinephrine has adverse cardiovascular effects, such as arrhythmia, pulmonary edema, and even cardiac arrest. We have experienced epinephrine-induced cardiovascular crisis, with severe hypertension, tachycardia, and cardiac arrest after subcutaneous infiltration of a 2% lidocaine and 1 :...

PURPOSE To compare the cardiopulmonary effects and the quality of anesthesia of the extradural lidocaine in combination with fentanyl or morphine in bitches undergoing ovariohysterectomy. METHODS Sixteen female dogs, were sedated with intramuscular acepromazine (0.05 mg kg-1), followed by anesthetic induction with intravenous propofol (4 mg kg-1), to perform the lumbosacral puncture. The anim...

A patient-specific, stepped approach to topical and intranasal analgesic pharmacotherapy was effective in reducing refractory postherpetic neuralgia (PHN) not responding to the current standard of care for PHN. The use of topical analgesic therapy allowed for higher concentrations of medication locally while reducing the likelihood of systemic side effects common to the drugs used. No adverse e...

OBJECTIVE Fine-needle aspiration biopsy (FNAB) is a mandatory procedure in evaluation of thyroid nodules. However, it is sometimes perceived as a painful procedure by the patients. Efficacy of the needle-free injection of local anesthesia for reducing the pain associated with other cutaneous procedures that involve needle insertion was previously reported. In this double-blind, placebo-controll...

BACKGROUND Lidocaine demethylates deoxyribonucleic acid (DNA) in breast cancer cells. This modification of epigenetic information may be of therapeutic relevance in the perioperative period, because a decrease in methylation can reactivate tumour suppressor genes and inhibit tumour growth. The objectives of this study were to determine the effect of two amide local anaesthetics, ropivacaine and...

BACKGROUND Topical anesthetics, unlike injectable anesthetics, can be applied painlessly and can provide sufficient pain control to maintain patient comfort throughout a variety of laser procedures. Although the use of topical lidocaine is considered relatively safe, instances of cardiotoxic and neurotoxic adverse events have been reported to occur. OBSERVATIONS A 52-year-old woman underwent ...

Background: Scabies is one of the health care problems in our community and is an endemic problem at any time. Its current therapy in Iran is lindane 1% lotion, which is deleted from market in many countries because of multiple side effects and better alternatives. The aim of this study was to evaluate the efficacy and side effects of lindane in patients with scabies and to replace lindane with...

the present study was designed to assess the efficacy of fentanyl and pancuronium combined with dilute lidocaine solution for axillary block. onehundred adult patients undergoing upper limb surgery were randomly allocated to receive either 0.6 ml/kg of 1 % lidocaine (6 mg/kg) or 0.6 mllkg of 0.5% lidocaine (3 mg/kg) with 1 µg/kg of fentanyl and 0.5 mg of pancuronium. the onset of sensory and mo...

conclusions the volume of the injected anesthetic accelerated the onset of sensory and motor block without affecting the rate of success in our patients. results the onset of sensory and motor block was significantly shorter in the 1.3% lidocaine group than in the 2% lidocaine group (p ≤ 0.05). the success rate of sensory and motor block was not different. the quality (completeness) of sensory ...