BACKGROUND The association between the risk of orofacial clefts in infants and the use of corticosteroids during pregnancy is unclear from the available evidence. We conducted a nationwide cohort study of all live births in Denmark over a 12-year period. METHODS We collected data on all live births in Denmark from Jan. 1, 1996, to Sept. 30, 2008. We included live births for which information ...

Non-syndromic cleft lip with or without cleft palate (CL/P) is one of the most common congenital anomalies world wide. It has a prevalence of approximately 1/1000 among white populations and 1/600 among Thai newborns. Environmental and genetic factors have been implicated in CL/P and several different loci and genes have been associated with them. Maternal folic acid supplementation during earl...

Background Oral clefts are among the common congenital birth defects with a broad phenotypic gamut. Since the epidermal ridges of the fingers and palms as well as the facial structures like lip, alveolus, and palate are formed from the same embryonic tissues during the same embryonic period, the genetic and environmental factors responsible for causing cleft lip and palate might also affect der...

The objective of this study was to investigate the prevalence of live births with orofacial clefts in Brazil from 2009 to 2013, according to Brazil's federative units and regions, and correlate it with the number of corrective surgery procedures for cleft lip and palate performed through the Brazilian National Health System in the same period. The data were collected from the National Live Birt...

OBJECTIVES Evidence suggests that parental occupation and Hispanic ethnicity may be risk factors for some birth defects. Because few studies have examined the effect of Hispanic ethnicity on occupational associations, we examined whether risk associated with certain occupations was heightened in Hispanics compared with non-Hispanic Whites. DESIGN In this case-control study among Texas births ...

Many mechanisms underlying normal and abnormal craniofacial embryogenesis are well understood. The genetic factors that provoke abnormal development and result in orofacial clefts are not clear, but much progress has occurred in our understanding. Genes or chromosomal rearrangements on many chromosomes can lead to syndromes that include orofacial clefts. This diversity in the mechanisms that ca...

Non-syndromic cleft lip with or without cleft palate (CL/P) is one of the most common congenital anomalies world wide. It has a prevalence of approximately 1/1000 among white populations and 1/600 among Thai newborns. Environmental and genetic factors have been implicated in CL/P and several different loci and genes have been associated with them. Maternal folic acid supplementation during earl...