BACKGROUND Congenital abnormalities of the heart and cardiovascular system are reported in almost 1% of live births, and about half of these children need medical or surgical help in infancy. In the first decade, a further 25% require surgery to maintain or improve their life. Only 10% survive to adolescence without treatment. Of these 10%, however, many live a normal life for years before thei...

Congenital heart diseases are traditionally considered to be multifactorial in pathogenesis resulting from environmental and genetic interactions that determine penetrance and expressivity within a genetically predisposed family. Recent evidence suggests that genetic contributions have been significantly underestimated. However, single gene defects occur only in a minority of cases, and multige...

• Several epidemiological studies" have shown a positive correlation between viral diseases early in pregnancy and congenital heart disease in human beings. Since viral diseases are accompanied commonly by fever, it was considered important to investigate the effect of high temperature alone on the development of the heart in chick embryos. It was also thought that incubation at low temperature...

anomalous origin of the left coronary artery from the pulmonary artery (alcapa) is a rare congenital cardiac malformation. we report three cases of alcapa who survived to adulthood. the first case was a 51-year-old woman who complained of typical chest pain that was diagnosed with alcapa using cardiac catheterization and coronary computed tomographic angiography (cta). the second case was a 30-...

the purpose of this study was to evaluate the early and late outcome after total correction of tetralogy of fallot (tof) in 101 consecutive patients with a mean age of 8.23 ± 4.90 years underwent repair of surgery at one institution between 1995 and 2006. forty two patients had initial palliative operations. a transannular patch was inserted in 60 (58.5%) patients. risk factors for operative mo...

background and objective: congenital heart disease (chd) is the most form of cardiovascular disease in children. chd have different presentations, from defects that progress asymptomatically to those with significant symptoms and high mortality. this study was performed to highlight the importance of signs and symptoms to diagnosis of chd neonates. materials & methods: this descriptive an...

conclusions in the children in this study, pacemaker accelerometers failed to meet physiological demands. results basal heart rates, maximal heart rates, and exercise tolerance were significantly lower in the children with pacemakers. age, sex, and body mass index had no effect on the heart rate slope during the exercise test. there was no significant difference between epicardial and endocardi...

Bicuspid aortic valve (BAV) is the most common congenital abnormality of the heart. In this condition, instead of three cusps, the aortic valve has two cusps. Children with congenital heart diseases are at increased risk of developing oral diseases, such as: higher number of decayed teeth, developmental anomalies, periodontal disease, malocclusion, dental crowding, as well as susceptibility to ...

Congenital heart defects are the most common malformations at birth. Due to the fact that the developmental windows at early stages close rapidly, the aim of this study was to determine the impact of congenital heart defects on the central nervous system at short and medium terms after applying traditional and quantitative electroencephalography techniques and a test of neurodevelopment. Twenty...