Cohen: Early reports suggested that benzodiazepines, specifically diazepam, were associated with higher risk of cleft lip and/or cleft palate in children exposed during the first trimester, but several subsequent reports did not replicate that finding. Over the next decade or so, a number of investigators studied effects of individual benzodiazepines and benzodiazepines as a class, but the meth...

A general idea of the magnitude of the problem can be drawn from studies of the occurrence of the common clefts of the lip and palate (Davis (1935) found four median clefts of the lip and five oblique facial clefts in a series of 937 examples of common clefts of the lip and palate. Blackfield and Wilde (1950) noted only five lateral (transverse) facial clefts during a period in which they obser...

Aim: to evaluate the surgical effects of two rehabilitation protocols on dental arch occlusion 5-year-old children with or without cleft lip and palate. Methods: this is a retrospective longitudinal study sample comprised 45 digitized casts divided into followed groups: Group 1 (G1) – who underwent cheiloplasty (Millard technique) at 3 months one-stage palatoplasty (von Langenbeck 12 months; 2 ...

Objective(s):We investigated the influence of genetic variation of the transforming growth-factor alpha (TGFA) locus on the relationship between smoking and oral clefts. Materials and methods:In this study 105 Iranian infants with non-syndromic cleft lip/palate and 218 controls with non-cleft birth defects were examined to test for associations among maternal exposures, genetic markers, and ora...

objective(s):we investigated the influence of genetic variation of the transforming growth-factor alpha (tgfa) locus on the relationship between smoking and oral clefts. materials and methods:in this study 105 iranian infants with non-syndromic cleft lip/palate and 218 controls with non-cleft birth defects were examined to test for associations among maternal exposures, genetic markers, and ora...

orofacial clefts, including cleft lip with or without cleft palate (cl (p)), are common congenital malformations, second only to clubfoot in frequency of occurrence. the epidemiology and genetics of this disorder have been studied extensively in various countries by several investigators. the objective of this study is to assess the epidemiology and some genetic aspects of orofacial clefting at...