Consideration of slamming loads within the structural design planning hulls is critical importance in ensuring adequate performance. However, a general engineering theory for has yet to be uncovered due intricacy interplay between complex fluid flows and nonlinear deformations, so relies on specialized theories. We propose one such case that has, until now, eluded proper description. In pursuit...

The inositol phosphatases phosphatase and tensin homologue (PTEN) and Src homology 2 domain-containing inositol phosphatase (SHIP) negatively regulate phosphatidylinositol-3-kinase (PI3K)-mediated growth, survival, and proliferation of hematopoietic cells. Although deletion of PTEN in mouse T cells results in lethal T cell lymphomas, we find that animals lacking PTEN or SHIP in B cells show no ...

With the rapid development of spaceborne synthetic aperture radar (SAR) and the increasing need of ship detection, research on adaptive ship detection in spaceborne SAR imagery is of great importance. Focusing on practical problems of ship detection, this paper presents a highly adaptive ship detection scheme for spaceborne SAR imagery. It is able to process a wide range of sensors, imaging mod...

In this paper, we analyze the state-of-the-art replacement policy based on Signature-Based Hit Prediction (SHiP). While we observe that the proposed SHiP implementation improves performance over the LRU policy on all configurations, we identify three areas of improvement. First, the policies for updating the counters in the Signature History Counter Table (SHCT) can be modified. Second, a broad...

BACKGROUND: The 'drip-and-ship' paradigm denotes a treatment regimen in patients in whom intravenous (IV) recombinant tissue plasminogen activator (rt-PA) is initiated at the emergency department (ED) of a community hospital, followed by transfer within 24 h to a comprehensive stroke center. Although the drip-and-ship paradigm has the potential to increase the number of patients who receive IV ...

Semi-submersible offshore platforms play a vital role in deep-sea energy exploitation. However, the vast waves threaten platform’s operation, usually leading to severe consequences. It is essential study wave-slamming mechanism of under extreme wave conditions. Existing research simplifies platform slamming problem. This paper establishes model semi-submersible and flexible mooring system numer...

BACKGROUND Dendritic cells (DCs) not only play a crucial role in activating immune cells but also suppressing them. We recently investigated SHIP's role in murine DCs in terms of immune cell activation and found that TLR agonist-stimulated SHIP-/- GM-CSF-derived DCs (GM-DCs) were far less capable than wild type (WT, SHIP+/+) GM-DCs at activating T cell proliferation. This was most likely becaus...

Ship detection is an inherent process supporting tasks such as fishery management, ship search, marine traffic monitoring and control, and helps in the prevention of illegal activities. So far, sea and shore monitoring has been carried out by ship patrols and aircrafts along with sea vessel detection from data from space-borne platforms. Recently an increase interest in applying images delivere...

Ship is a recently identified SH2-containing inositol polyphosphate 5-phosphatase that has been implicated as an important signaling molecule in cell-culture systems. To understand the physiologic function of Ship in vivo, we performed expression studies of Ship during mouse development. Results of this study demonstrate the expression of ship to be in late primitive-streak stage embryos (7.5 d...