background and objectives: given the limited number of studies on ramadan fasting and military performance, we conducted this study to identify the effect of ramadan fasting on physical fitness performances in army cadets. methods: twenty healthy males were randomly selected from a larger sample group. the subjects were divided into fasting (n=10) and non-fasting (n=10) groups. they performed v...

Ups1p, Ups2p, and Ups3p are three homologous proteins that control phospholipid metabolism in the mitochondrial intermembrane space (IMS). The Ups proteins are atypical IMS proteins in that they lack the two major IMS-targeting signals, bipartite presequences and cysteine motifs. Here, we show that Ups protein import is mediated by another IMS protein, Mdm35p. In vitro import assays show that i...

The presence of intracellular ubiquitylated inclusions in neurodegenerative disorders and the role of the ubiquitin/proteasome system (UPS) in degrading abnormal hazardous proteins have given rise to the hypothesis that UPS-impairment underlies neurodegenerative processes. However, this remains controversial for polyglutamine disorders such as Huntington disease (HD). Whereas studies in cellula...

A variety of neurological disorders and polyglutamine (polyQ) diseases are caused by misfolded proteins. The common feature of these diseases is late-onset cellular degeneration that selectively affects neurons in distinct brain regions. polyQ diseases, including Huntington's disease (HD), present a clear case of selective neurodegeneration caused by polyQ expansion-induced protein misfolding, ...

Ubiquitin-proteasome system (UPS) mediated proteolysis is responsible for the degradation of majority of cellular proteins, thereby playing essential roles in maintaining cellular homeostasis and regulating a number of cellular functions. UPS dysfunction was implicated in the pathogenesis of numerous disorders, including neurodegenerative disease, muscular dystrophy, and a subset of cardiomyopa...

Annaël Brunet, 2, 3, 4 Catherine Tardin, 2 Laurence Salomé, 2 Philippe Rousseau, 6 Nicolas Destainville, 4 and Manoel Manghi 4 Institut de Pharmacologie et Biologie Structurale, UMR CNRS-UPS 5089, 31062 Toulouse, France Université de Toulouse, UPS, Institut de Pharmacologie et Biologie Structurale, 31062 Toulouse, France Université de Toulouse, UPS, Laboratoire de Physique Théorique (IRSAMC), 3...

Alterations in cellular structure and synapse composition are central to proper nervous system function. Recent work has identified the ubiquitin-proteasome system (UPS) as a key regulator of neuronal biology. The UPS is essential for the growth and development of immature neurons and is a critical mediator of synaptic adaptability in mature neurons. Furthermore, proteinaceous deposits that acc...

BACKGROUND Alexithymia is thought to be associated with the development of medically unexplained physical symptoms (UPS). So far little research has been published on alexithymia as a risk factor for the persistence of UPS. OBJECTIVE To determine the clinical outcome in UPS patients and to study the relative importance of alexithymia in predicting that outcome. METHODS A follow-up study was...

Postoperative epidural analgesia often needs rate readjustment using top-ups. Patient-controlled epidural analgesia (PCEA) is said to reduce the requirement of epidural top-ups when compared to continuous epidural analgesia (CEA). We compared CEA and PCEA in major thoracic and abdominal surgery, in a cohort study. The primary endpoint was the required number of epidural top-ups. Secondary endpo...

New technology based start-ups play a very important role in developing the economy of a country. In India, telecom sector has seen unprecedented growth over the last decade and this has led to emergence of several telecom related start-ups. However, product based B2B start-ups are rare and existing ones have to undergo several challenges in commercializing. Surprisingly not much research work ...