2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a by-product o f t he trichlorophenol (herbicide) production and is also produced through a variety of combustion processes. It appears that TCDD is a ubiquitous chemical, particularly in industrialised countries, and the liver is the target organ of its toxicity. The prominent hepatotoxic effect of TCDD is progressive centrilobular necrosis. Th...

the incidence of drug induced liver injury (dili) is about 1/1000 to 1/10000 among patients who receive therapeutic drug doses. drug induced hepatotoxicity is a major cause of acute and chronic liver disease. the severity of liver damage ranges from nonspecific changes in liver structure to acute liver failure, cirrhosis and liver cancer. some common agents that can cause liver injury are aceta...

tacrolimus, a cornerstone of immunosuppressive therapy in solid organ transplantation, has a narrow therapeutic range with considerable inter-individual and intra-individual pharmacokinetic variability. to date, there is no information on the pharmacokinetics of tacrolimus in iranian liver transplant recipients. this study was designed to determine pharmacokinetic properties of orally administe...

background and objective: obesity in childhood increases the risk of fatty liver disease. with respect to the increased prevalence of obesity in iran and the world, this study aimed to investigate the relationship between fatty liver and obesity in 6 -18 year-old children. methods: in this case-control study, 25 overweight children and 24 obese children, who had inclusion criteria, were selecte...

background: we aimed at evaluating the toxicity effects of low (subtoxic) concentrations of silver nanoparticles (agnp, 5-10 nm) in human hepatoblastoma (hepg2) cell line after and during a period of about one month. methods: xtt and mtt assays were used to draw a dose-response curve ic50 (half maximal inhibitory concentration) value of the agnp on hepg2 cells was calculated to be 2.75-3.0 mg/l...

patients and methods tae was performed on 20 patients with liver hemangioma. the embolic agent used was polyvinyl alcohol (pva) particles (300-400 micron, jonson and johnson cordis, usa). all patients were followed up for 6 months. imaging was carried out and patients were also evaluated symptomatically through telephone interview by a physician. results twenty patients aged from 21 to 63 years...

conclusions besides, there are some novel agents, yet under research, which could affect the future of anesthetic agents' fate regarding their hepatic effects. results however, we have evidence that there is some concern regarding their effects on the liver cells. fortunately not all the anesthetics are blamed and even some could be used safely, based on the available evidence. evidence acquisi...

background there is still no suitable mice model that can completely mimic the human fulminant hepatitis, which sets a block for drug effect evaluation and mechanism researching of human fulminant hepatitis. objectives the aim of this study was to establish an animal model able to mimic the main features of human fulminant hepatitis. materials and methods dimethylnitrosamine (dmn) was peritonea...

backgrounds: g6pd deficiency is the most common enzymopathy of red blood cells. the clinical symptoms of favism are jaundice, hematuria and haemolytic anaemia that seem to affect liver and kidney in long term. thus we evaluate kidney and liver function of favism patients in an endemic area of the disease with a high rate of fava beans cultivation. methods: this study was performed on favism pat...