BACKGROUND The worldwide burden of the Group A Streptococcus (GAS) primary infection and sequelae is considerable, although immunization programs with broad coverage of the hyper variable GAS are still missing. We evaluate the streptococcal hemoprotein receptor (Shr), a conserved streptococcal protein, as a vaccine candidate against GAS infection. METHODS Mice were immunized intraperitoneally...

-We investigated flow (shear stress)- and agonist-induced cGMP release in mesenteric vascular beds of spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY). The mesenteric vascular bed was perfused in situ with Tyrode's solution. Vascular relaxation and cGMP release in the perfusate were determined on stimulation by flow or by acetylcholine (0.1 micromol/L) or sodium ni...

Recognizing TimeML events and identifying their attributes, are important tasks in natural language processing (NLP). Several NLP applications like question answering, information retrieval, summarization, and temporal information extraction need to have some knowledge about events of the input documents. Existing methods developed for this task are restricted to limited number of languages, an...

همدقم : نیئتورپ S100B ورون طابترا لرتنک رد و دوش یم دازآ اه تیسورتسآ زا هک تسا ینیئتورپ ، لگ ی یلا دراد شـقن یسپانیس يریذپ لکش و هظفاح رد لاامتحا و . هـعلاطم ادروخرب یصاخ تیمها زا نورون و تیسورتسآ لولس ود يدرکلمع طابترا تسا ر . ياـه شوـم رد يریگداـی يور رـب پـماکوپیه نورد هـب نیئتورـپ نیا قیرزت رثا رضاح هعلاطم رد تفرگ رارق یسررب دروم ییارحص . شور اه : زا قیقحت نیا رد 40 دش هدافتسا رن ییا...

Regional cerebral blood flow (rCBF) was measured in normotensive rate (NTR) and spontaneously hypertensive rats (SHR), in a lightly anesthetized state and with control of PaCO2 by artificial ventilation. Without carotid artery ligation, NTR and SHR showed almost identical rCBF values and distribution, despite significantly elevated levels of blood pressure in SHR. Bilateral carotid artery ligat...

Intracellular Mg2+ depletion has been implicated in vascular dysfunction in hypertension. We demonstrated that transient receptor potential melastatin 7 (TRPM7) cation channels mediate Mg2+ influx in VSMCs. Whether this plays a role in [Mg2+]i deficiency in hypertension is unclear. Here, we tested the hypothesis that downregulation of TRPM7 and its homologue TRPM6 is associated with reduced [Mg...

We tested the hypothesis that the exaggerated natriuretJc response of spontaneously hypertensive rats (SHR) to intragastric volume expansion may be independent of the sustained level of arterial pressure. The SHRs were treated for 10 days with guanethldine S04, 25 mg/llter, and hydralazine HO, 80 mg/liter, in drinking water. Mean arterial pressure (MAP) in conscious treated SHRs (T-SHR) was 130...

Inbred Munich Wistar Frömter [MWF/FubRkb (RGD:724569), MWF] rats develop progressive albuminuria with age that is under polygenetic influence. We previously identified a major albuminuria quantitative trait locus (QTL) on rat chromosome (RNO)8 in MWF. To test the independent role of QTL(s) for albuminuria development on RNO8, we generated a consomic SHR-Chr 8(MWF)/Rkb (SHR-8(MWF)) strain by tra...

This study was designed to test the hypothesis that stimulation of nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phosphate (NADH/NADPH) oxidase is involved in increased vascular superoxide anion (*O(2)(-)) production in spontaneously hypertensive rats (SHR). The study was performed in 16-week-old and 30-week-old normotensive Wistar-Kyoto rats (WKY(16) and WKY(30), respecti...

To elucidate functional changes in the vascular smooth muscle of spontaneously hypertensive rats (SHR) after chronic inhibition of angiotensin converting enzyme, we examined the contractile responses to different pharmacological interventions in the isolated aortas from SHR treated with a novel angiotensin converting enzyme inhibitor, CS-622 (10 mg/kg/day) for 20 weeks. In normal K+ medium, a m...