نتایج جستجو برای: btz
تعداد نتایج: 813 فیلتر نتایج به سال:
A series of acceptor1–donor–acceptor2 (A1–D–A2)-type copolymers was designed and synthesized using thiophene as an electronrich unit and benzothiadiazole (BT) and benzotriazole (BTz) as electron-deficient moieties. A weaker acceptor, BTz, was incorporated as a solubilizing moiety with three tetradecyl (or tetradecyloxy) side chains, and a stronger acceptor, BT, was substituted with different nu...
We have studied the charged BTZ black holes in noncommutative spaces arising from two independent approaches. First, by using Seiberg-Witten map followed a dynamic choice of gauge Chern-Simons theory. Second, inducing fuzziness mass and charge Lorentzian distribution function with width being same as minimal length associated noncommutativity. In first approach, we found existence non-static no...
New chemotherapeutic compounds are needed to combat multidrug-resistant Mycobacterium tuberculosis (Mtb), which remains a serious public-health challenge. Decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1 enzyme) has been characterized as an attractive therapeutic target to address this urgent demand. Herein, we have identified a new class of DprE1 inhibitors benzothiazinethiones as antituber...
We explicitly show that in (2+1) dimensions the general solution of the Einstein equations with negative cosmological constant on a neigbourhood of timelike spatial infinity can be obtained from BTZ metrics by coordinate transformations corresponding geometrically to deformations of their spatial infinity surface. Thus, whatever the topology and geometry of the bulk, the metric on the timelike ...
In this paper, we considered cosmological constant as a variable and studied properties and the thermodynamics stability of BTZ black hole from a geometric perspective. Also, we examined the correspondence between thermodynamic curvature singularities and phase transitionpoints with different thermodynamic metrics. We found that theQuevedo metric cannot predict the phase transition points in tw...
Bortezomib (BTZ) is a first-in-class proteasome inhibitor approved for the therapy of multiple myeloma that also displays unique regulatory activities on immune cells. The enzyme indoleamine 2,3-dioxygenase 1 (IDO1) is a tryptophan metabolizing enzyme exerting potent immunoregulatory effects when expressed in dendritic cells (DCs), the most potent antigen-presenting cells capable of promoting e...
We report here two series of coordination polymer chains: the first being [M(II)(ox)(bnz)(2)](n) (M = Mn 1, Fe 2, Co 3, Ni 4, Cu 5 and Zn 6; ox = oxalate C(2)O(4)(2-); bnz = benzimidazole) and the second [M(II)(ox)(btz)(2)](n) (M = Mn 7, Fe 8, Co 9, Ni 10, Cu 11 and Zn 12; btz = benzotriazole). The first series displays an unusual homometallic [-M(i)-M(ii)-M(ii)-](n) chain topology and the seco...
Proteasome inhibitors (PI), mainly targeting the β5 subunit of the 20S proteasome, are widely used in the treatment of multiple myeloma (MM). However, PI resistance remains an unresolved problem in the therapy of relapsed and refractory MM. To develop a new PI that targets other proteasome subunits, we examined the anti-MM activity of a novel syringolin analog, syringolog-1, which inhibits the ...
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