Standard isotropic culture fails to recapitulate the spatiotemporal gradients present during native development. Cartilage grown from human mesenchymal stem cells (hMSCs) is poorly organized and unstable in vivo. We report that human cartilage with physiologic organization and in vivo stability can be grown in vitro from self-assembling hMSCs by implementing spatiotemporal regulation during ind...

The purpose of our study is to investigate whether there is an age-related change in T1 rho values and to evaluate the effects of weight bearing on age-related increase in T1 rho values of normal cartilage. Thirty-two asymptomatic patients were examined using a 3.0T MRI to determine knee cartilage T1 rho values. Femorotibial and patella cartilage was defined as weight-bearing cartilage (WB-...

OBJECTIVES This study was designed to evaluate the normal development of the nasal septum in Koreans using sagittal MRI for the valuable clinical information on septal procedures. METHODS Two hundred eighty patients who had their whole nasal septum visualized in the midline sagittal view were selected among the 3,904 patients with brain MRI from January, 2004 to December, 2006 at Dankook Univ...

Hyaline cartilage development is essential in pediatric musculoskeletal growth. Although in an adult patient, we focus solely on the articular cartilage, in the pediatric population, the articular, epiphysial and physial cartilage play an important role in skeletal maturation. The epiphysial and physial cartilage participate in enchondral ossification and contribute to a child’s longitudinal gr...

BACKGROUND It is difficult to repair cartilage damage when cartilage undergoes trauma or degeneration. Cartilage tissue engineering is an ideal treatment method to repair cartilage defects, but at present, there are still some uncertainties to be researched in cartilage tissue engineering including the mechanical properties of the repaired region. METHODS In this study, using an agarose gel a...

Lunatum Cartilage 1 Cartilage 2 Cartilage 3 Cartilage 4 Cartilage 5 Cartilage 6 TFCC Median Nerve 3T 6.45 ± 0.58 19.57 ± 2.49 20.79 ± 1.29 18.07 ± 1.58 17.99 ± 1.97 17.79 ± 1.79 18.42 ± 2.03 10.77 ± 2.04 20.66 ± 2.40 7T 6.39 ± 0.72 28.42 ± 2.69 28.13 ± 1.29 24.49 ± 5.00 22.91 ± 6.38 35.62 ± 7.57 35.80 ± 6.24 21.24 ± 3.17 39.97 ± 17.04 A comparison of wrist MRI at 3T and 7T using adjustable rece...

OBJECTIVE To determine the influence of IL-1 beta on the presence and the distribution of tenascin in matrix of human normal and osteoarthritic cartilage explants. METHODS Cartilage was grown in organotypic culture with or without IL-1 beta (10 ng ml1). Tenascin antigen was detected on cryopreserved cartilage sections by immunohistochemical techniques with a monoclonal antibody directed again...

The significance of the adjacent cartilage in cartilage defect healing is not yet completely understood. Furthermore, it is unknown if the adjacent cartilage can somehow be influenced into responding after cartilage damage. The present study was undertaken to investigate whether the adjacent cartilage can be better sustained after microfracturing in a cartilage defect model in the stifle joint ...

Cartilage has a limited regenerative capacity. Faced with the clinical challenge of reconstruction of cartilage defects, the field of cartilage engineering has evolved. This article reviews current concepts and strategies in cartilage engineering with an emphasis on the application of nanotechnology in the production of biomimetic cartilage regenerative scaffolds. The structural architecture an...

Joints that have degenerated as a result of aging or injury contain dead chondrocytes and damaged cartilage. Some studies have suggested that chondrocyte death precedes cartilage damage, but how the loss of chondrocytes affects cartilage integrity is not clear. In this study, we examined whether chondrocyte death undermines cartilage integrity in aging and injury using a rapid 3D confocal carti...