نتایج جستجو برای: adipose

تعداد نتایج: 47208  

2015
Gijs H. Goossens Ellen E. Blaak

The number of studies in the field of adipose tissue biology has increased exponentially over the last decade. This shift in research focus is primarily driven by the tremendous increase in the prevalence of obesity and related chronic diseases, including cardiovascular disease and type 2 diabetesmellitus. Adipose tissue is a fascinating and complex organ, with marked effects on whole-body phys...

2014
Sasikumar J. Soumya Sheela Binu Antony Helen Pallu Reddanna Perumana R. Sudhakaran Cheorl-Ho Kim

Inflammation is critical in the dysregulated growth of adipose tissue and associated vascular dysfunctions. 15-Lipoxygenase metabolites, important mediators of inflammation in adipose tissue during obese conditions, may contribute to codependence of inflammation and angiogenesis in adipose tissue. We have already reported the pro-angiogenic effect of 15(S)-HETE in adipose tissue. The present st...

2012
Zhongxiao Wan Christopher G. R. Perry Tara Macdonald Catherine B. Chan Graham P. Holloway David C. Wright

BACKGROUND Adipose tissue mitochondria have been implicated as key mediators of systemic metabolism. We have shown that IL-6 activates AMPK, a mediator of mitochondrial biogenesis, in adipose tissue; however, IL-6(-/-) mice fed a high fat diet have been reported to develop insulin resistance. These findings suggest that IL-6 may control adipose tissue mitochondrial content in vivo, and that red...

2013
Tao Wang Anan Jiang Yanqin Guo Ya Tan Guoqing Tang Miaomiao Mai Haifeng Liu Jian Xiao Mingzhou Li Xuewei Li

Functional differences in the different types of adipose tissue and the impact of their dysfunction on metabolism are associated with the regional distribution of adipose depots. Here we show a genome-wide comparison between the transcriptomes of one source of subcutaneous and two sources of visceral adipose tissue in the pig using an RNA-seq approach. We obtained ~32.3 million unique mapped re...

2017
Yuwei Jiang Daniel C Berry Ayoung Jo Wei Tang Robert W Arpke Michael Kyba Jonathan M Graff

Adipose progenitor cells (APCs) reside in a vascular niche, located within the perivascular compartment of adipose tissue blood vessels. Yet, the signals and mechanisms that govern adipose vascular niche formation and APC niche interaction are unknown. Here we show that the assembly and maintenance of the adipose vascular niche is controlled by PPARγ acting within APCs. PPARγ triggers a molecul...

Journal: :Bioscience, biotechnology, and biochemistry 2009
Hiromi Yamashita Hitomi Maruta Michiyo Jozuka Rie Kimura Hiromi Iwabuchi Makiko Yamato Tsukasa Saito Katsuhiko Fujisawa Yoshitaka Takahashi Masumi Kimoto Miki Hiemori Hideaki Tsuji

We have reported that orally administrated acetate contributed to suppression of lipogenesis in the liver and to reduction of lipid accumulation in the adipose tissue of Otsuka Long-Evans Tokushima Fatty (OLETF) rats. The aim of this study was to investigate the effect of acetate on skeletal muscle and adipose tissues. Treatment with acetate showed a higher rate of oxygen consumption and a smal...

2013
Sam Virtue Antonio Vidal-Puig

In this review we discuss practical considerations for the assessment of brown adipose tissue in rodent models, focusing on mice. The central aim of the review is to provide a critical appraisal of the utility of specialized techniques for assessing brown adipose tissue function in vivo. We cover several of the most common specialized methods for analysing brown adipose tissue function in vivo,...

Javad Mohiti-Ardekani, Masaoud Rahmanian, Naeimeh Heiranizadeh, Reza Didehdar, Yousof Naghiaee,

Objective: Obesity is a factor in the development of insulin resistance and type 2 diabetes. Obesity contributes a wide variety of metabolic changes such as insulin resistance. The insulin signal mechanism to intra-cells occurs in insulin resistance, primarily in adipose tissue cells, which can be appropriate targets for therapeutic approaches by recognizing the proteins in this pathway. The st...

2015
Annelotte Philipsen Marit E. Jørgensen Dorte Vistisen Annelli Sandbaek Thomas P. Almdal Jens S. Christiansen Torsten Lauritzen Daniel R. Witte

AIMS Visceral adipose tissue measured by CT or MRI is strongly associated with an adverse metabolic risk profile. We assessed whether similar associations can be found with ultrasonography, by quantifying the strength of the relationship between different measures of obesity and indices of glucose metabolism in a population at high risk of type 2 diabetes. METHODS A cross-sectional analysis o...

Journal: :Cell metabolism 2008
Pazit Polak Nadine Cybulski Jerome N Feige Johan Auwerx Markus A Rüegg Michael N Hall

raptor is a specific and essential component of mammalian TOR complex 1 (mTORC1), a key regulator of cell growth and metabolism. To investigate a role of adipose mTORC1 in regulation of adipose and whole-body metabolism, we generated mice with an adipose-specific knockout of raptor (raptor(ad-/-)). Compared to control littermates, raptor(ad-/-) mice had substantially less adipose tissue, were p...

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