Quantitative measures of cartilage morphology (i.e., thickness) represent potentially powerful surrogate endpoints in osteoarthritis (OA). These can be used to identify risk factors of structural disease progression and can facilitate the clinical efficacy testing of structure modifying drugs in OA. This paper focuses on quantitative imaging of articular cartilage morphology in the knee, and wi...

Newborn and adult articular cartilage expresses bone (BMPs) and cartilage derived morphogenetic proteins (CDMPs). These morphogenetic proteins act over membrane receptors (BMPRs). We examined the expression pattern of BMP-7, BMP-3, CDMP-1, CDMP-2 and their receptors in adult normal and osteoarthritic, articular, knee cartilage. Immunostaining was carried out using polyclonal antibodies. The exp...

Articular cartilage damage is the primary cause of osteoarthritis. Very little literature work focuses on the microstructural damage mechanism of articular cartilage. In this article, a new numerical method that characterizes fluid coupling in particle model is proposed to study the damage mechanism of articular cartilage. Numerical results show that the damage mechanism of articular cartilage ...

Enders JT1, Otto TJ, Peters HC1, Wu J1, Moed BR1, +Zhang Z1 +1Saint Louis University, St. Louis, MO Senior author [email protected] INTRODUCTION: Cartilage repair continues to be a challenge, despite the progress made in engineering cartilage. One of the major obstacles hindering progression is the integration of the engineered constructs with the recipient cartilage. Cartilage integration is a u...

Optical reflection spectra of the cartilage/bone interface from hip joints of cows were studied. When comparing to ultrasonic measurement, it was found that cartilage thickness could be extracted using optical reflectance spectroscopy. For thicker cartilage layers, a high reflection for the wavelengths 400-600 was seen, and for thinner cartilage layers, the characteristic spectra of blood and b...

in this study the role of cell death in cartilage canal morphogenesis with morphometrical and histological methods was evaluated. the proximal tibial epiphysis of the chick embryos after fixation and decalcification at the 13 th and 18th days of incubation, with thick and semithin sections and h&e; ,tricromason and feulgen staining were studied. the rsulths were showed that cartilage canals wer...

BACKGROUND Magnetic resonance imaging (MRI) is increasingly used for research in hand osteoarthritis, but imaging the thin cartilage layers in the hand joints remains challenging. We therefore assessed the accuracy of MRI in detecting cartilage loss in patients with symptomatic osteoarthritis of the first carpometacarpal (CMC1) joint. METHODS Twelve patients scheduled for trapeziectomy to tre...

The main purpose of this in situ hybridization study was to investigate mRNA expression of three bone/cartilage matrix components (perlecan, DMP1, and MEPE) in developing primary (tibial) and secondary (condylar) cartilage. Perlecan mRNA expression was first detected in newly formed chondrocytes in tibial cartilage at E13.0, but this expression decreased in hypertrophic chondrocytes at E14.0. I...

In Situ Cartilage Repair article 2201588 by Xiong Shu, Sujun Wu, Juan Guan, and co-workers, a cell-free silk protein sponge is fitted on site of cartilage defect. The in situ repair assisted programmed factors E7 TGF-β1, that trigger serial events autologous stem cell homing, directed differentiation chondrocyte proliferation.