Alcohol is a commonly used drug that has many important health consequences. To understand its physiological effects and predict drug interactions it is important to understanding alcohol’s pharmacokinetics and the factors that influence it. A brief review of the absorption, distribution, metabolism, and excretion of alcohol is provided. Along with a discussion of important factors that influen...

Issues in Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents: Distribution in Tissue Markus Müller, Amparo dela Peña, and Hartmut Derendorf* Health Science Center, Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida, and Vienna General Hospital, Division of Clinical Pharmacokinetics, Department of Clinical Pharmacology, School of Medicine, V...

There were no significant differences in the pharmacokinetics of micafungin and expression of hepatic multidrug resistance-associated protein 2 (ABCC2/Mrp2) between analbuminemic and Sprague-Dawley rats. Micafungin bound strongly to high-density lipoprotein (HDL) and moderately to gamma globulin. These results suggest that HDL and gamma globulin contribute to the pharmacokinetics of micafungin.