Background & Aim: Policosanol is a component from main alcohol groups with long-chain that extracted from cane sugar. In the present research, the effect of policosanol was investigated on decrease of lipid metabolite levels in blood of hypercholesterolemia rats. Experimental: A number of 32 male Wistar rats race with average weight of 250 g was divided into four groups including negative cont...

common carp, cyprinus carpio (l.) were blood-sampled after 0, 2, 6, 12, 24, 48 and 72 h fasting to find serum baseline levels. there was a significant difference in serum glucose, lactate, triglyceride and total protein but not cholesterol, albumin and calcium levels among the treatments. glucose levels increased with fasting tine and reached to a peak after 6 h. then, the glucose level decreas...

The objective of this study was to determine the effects of diets having different fermentability on blood gases, blood metabolites and ruminal fermentation parameters in Holstein dairy cows. Four multiparous Holstein dairy cows (665 ± 25 kg BW, 170 ± 7.0 DIM and 15±1.5 kg of milk yield), fitted with rumen cannulae, were used in a 4×4 Latin Square design with 28-d periods. Corn starch and sucro...

A rapid, sensitive and reproducible HPLC method was developed and validatedfor the analysis of amifostine (AMF) and/or its metabolite, WR-1065 inhuman plasma. The method involves the alkylation of free sulfydryl group with iodoacetic acid followed by derivatization of the drug and its metabolite witho-phthaldialdehyde (OPA) andUVdetection at 340 nm. The derivatized AMF and WR-1065 were eluted i...

Imatinib is an orally administered tyrosine kinase inhibitor which inhibits the Bcr-Abl protein-tyrosine kinase with high selectivity. Imatinib is rapidly absorbed from the gut, after oral intake and has an almost absolute bioavailability of 98%. The metabolism of imatinib is mediated by the cytochrome P450 (CYP) isoenzymes in the liver and gut wall. CGP74588 is a major active metabolite of ima...

the objective of this study was to determine the effects of diets having different fermentability on blood gases, blood metabolites and ruminal fermentation parameters in holstein dairy cows. four multiparous holstein dairy cows (665 ± 25 kg bw, 170 ± 7.0 dim and 15±1.5 kg of milk yield), fitted with rumen cannulae, were used in a 4×4 latin square design with 28-d periods. corn starch and sucro...

BACKGROUND Prolonged breathing of nitric oxide reduces myocardial ischemia-reperfusion injury, but the precise mechanisms responsible for the cardioprotective effects of inhaled nitric oxide are incompletely understood. METHODS The authors investigated the fate of inhaled nitric oxide (80 parts per million) in mice and quantified the formation of nitric oxide metabolites in blood and tissues....

Currently, the majority of neonates born to organ recipient mothers on chronic immunosuppressive therapy are formula fed. However, over the past few years, evidence has grown, suggesting that breastfeeding might be possible and beneficial. We designed a study assessing the transfer of tacrolimus into the colostrum of posttransplant mothers. We assessed the amount of tacrolimus and its metabolit...

(99m)Tc-NC100668 [Acetyl-Asn-Gln-Glu-Gln-Val-Ser-Pro-Tyr(3-iodo)-Thr-Leu-Leu-Lys-Gly-NC100194] is a radiopharmaceutical imaging agent being developed to aid the diagnosis of thromboembolism. The stability profile of (99m)Tc-NC100668 was investigated by high-performance liquid chromatography (HPLC) after in vitro exposure to blood and plasma obtained from rat and human, as well as to urine and b...