BACKGROUND Juvéderm Volbella with Lidocaine is a new hyaluronic acid dermal filler. METHODS In this prospective, randomized, multicenter study, 280 subjects desiring lip volume enhancement were treated with Juvéderm Volbella with Lidocaine or Restylane-L. Investigators rated treatment outcomes on Allergan's Lip Fullness Scale, Perioral Lines Scale, and Oral Commissures Severity Scale. A blind...

In this investigation, three new crystal forms of lidocaine, and another lidocaine hydrochloride with hydroquinone, resorcinol, pyrogallol were synthetised. All the characterised using multiple techniques, PXRD, SC-XRD, DSC, FTIR. The stability was studied, and, for more stable forms, i.e., (lidhcl) solubility determined through FTIR analysis. crystalline obtained coformers showed an interestin...

Background: Visceral and shoulder painare among the most frequent reported pain after laparoscopic cholecystectomy (LC). Objectives: To investigate effectiveness clinical value of rectal indomecthacin and  intraperitoneal lidocaine  for treating cholecystectomy. Patients methods: In Qena university hospital, this prospective randomized comparative study was conducted, 80 patients were schedul...

Lallemantia royleana (Balangu) is a well known Iranian medicinal plant that its seed mucilage has many applications in modern pharmacology. Plant mucilage traditionally was used as a gel supplement, and natural matrix for sustained release of drugs. But it seems that these compounds are not a simple additive and also have many undiscovered pharmacological properties. In this research, the anest...

Abstract Objective: To evaluate and compare the analgesic effects of caudal epidural administration of lidocaine (LIDO), caudal laser radiation and epidural lidocaine plus laser radiation in horses. Study design: A blinded, randomized, prospective, experimental cross-over study. Animals: Five healthy horses, 15.7 +/- 4.9 years of age, weighing 240 +/- 37 kg. Methods: The...

BACKGROUND A low concentration of lidocaine (10 microM) has been shown to reduce anoxic damage in vitro. The current study examined the effect of low-dose lidocaine on infarct size in rats when administered before transient focal cerebral isehemia. METHODS Male Wistar rats (weight, 280-340 g) were anesthetized with isoflurane, intubated, and mechanically ventilated. After surgical preparation...

BACKGROUND Perioperative myocardial ischemia poses a vital threat to surgical patients. Means to protect postischemic myocardium are clinically not available. Lidocaine has been demonstrated to exert antiinflammatory pleiotropic effects. The authors set out to test if lidocaine protects ischemic myocardium from reperfusion injury. METHOD A mouse model of transient coronary artery ligation (30...

The mechanism of interaction of lidocaine with cardiac sodium channels during use-dependent block is not well defined. We examined the blockade of single cardiac sodium channels by lidocaine and its hydrophobic derivative RAD-242 in rabbit ventricular myocytes. Experiments were performed in cell-attached and inside-out patches. Use-dependent block was assessed with trains of ten 200-msec pulses...

BACKGROUND Awake tracheal intubation may evoke reflex bronchoconstriction in asthmatics. Whether this effect is altered by the choice of the local anesthetic used or by pretreatment with a beta2-adrenoceptor agonist is unknown. Therefore, we assessed the effect of awake fiberoptic intubation after lidocaine or dyclonine inhalation with or without pretreatment with salbutamol on lung function in...

BACKGROUND Limitations to the use of lidocaine for intravenous regional anaesthesia (IVRA) include lack of optimal intraoperative analgesia and systemic toxic reactions. This randomized double-blind study was conducted to compare intraoperative and postoperative analgesia, adverse effects, and plasma concentrations of mepivacaine or lidocaine, on release of the tourniquet in patients undergoing...