A novel vaccine against serogroup B meningococcal disease - containing a combination of protein antigens identified by reverse vaccinology: fHBP fused to GNA2091, GNA2132 fused to GNA1030, and NadA - is currently in Phase III clinical trials. In order to determine the role of these antigens in the growth, survival and fitness of the meningococcus, we generated a mutant lacking the expression of...

While the importance of Ca(2+) channel activity in axonal path finding is established, the underlying mechanisms are not clear. Here, we show that transient receptor potential vanilloid receptor 1 (TRPV1), a member of the TRP superfamily of nonspecific ion channels, is physically and functionally present at dynamic neuronal extensions, including growth cones. These nonselective cation channels ...

Objective: This study compared the effect of abdominal exercise versus ultrasound cavitation on coronary risk profile in obese women by 6 week program. Material and Methods: Forty obese women with abdominal obesity, their age ranged from (30-40) years, their BMI (30-35kg/m), WHR ranged between (0.81 to 1.0) selected from Ibrahim nada hospital, and divided into two equal groups. Group (A): Recei...

La tesis de este artículo es que la interpretación Nietzsche realiza del nihilismo, particularmente en genealogía moral, no se puede entender sin una reflexión sobre cómo y Schopenhauer conciben el ascetismo. Aunque formula «voluntad nada» pertenece a también expresa un modo considera voluntad ascética –la él ve detrás todas las formas ascetismo sitúa «ideal ascético». En «nihilismo» precisamen...

During bacterial pathogenesis extensive contacts between the human and the bacterial extracellular proteomes take place. The identification of novel host-pathogen interactions by standard methods using a case-by-case approach is laborious and time consuming. To overcome this limitation, we took advantage of large libraries of human and bacterial recombinant proteins. We applied a large-scale pr...

Kesenian Nandong adalah seni vokal yang diwariskan secara turun-tumurun pada masyarakat Simeulue. merupakan sejenis tutur syair-syairnya berisikan karangan mengandung nasehat, sindiran, rintihan dilantunkan dengan iringan alat musik yaitu kedang/gendang dan biola. menggunakan bahasa Devayan khas Simeulue, namun dalam kesenian juga Aneuk Jamee. Keunikan selain terdapat Jamee nada tinggi melengki...

This paper introduces fundamental ideas of bitopological dynamical systems. Here, notions transitivity, point pairwise iterated compactness, weakly etc. are introduced. Later, it is shown that under homeomorphism, transitivity implies transitivity. Moreover, homeomorphism; compactness and found to be equivalent. we apply our results in the development process a human embryo from zygote until bi...