نتایج جستجو برای: blood metabolite
تعداد نتایج: 741497 فیلتر نتایج به سال:
The role of hepatic intrinsic clearance for metabolite formation from various precursors on subsequent metabolite elimination was was investigated in the once-through perfused rat liver preparation. Two pairs of acetaminophen precursors: [14C] phenacetin-d5 and [3H] phenacetin-do, [14C] acetanilide and [3H] phenacetin were delivered by constant flow (10 ml/min/liver) either by normal or retrogr...
We propose a new drug - "Rheoambrasol" which includes substance of plant origin (complex compounds polysaccharide and natural metabolite) non-toxic, environmentally friendly has wide functional capabilities as means capable correcting the consequences methemoglobinemia, restoring structural properties cells preserving their viability. The aim work is to study effect blood substitute on morpholo...
Acebutolol (AC) is a chiral b-adrenergic blocking drug, which is useful clinically as the racemate in treating hypertension and is metabolized to an equipotent chiral metabolite, diacetolol (DC). In this paper we report a case of a 32 year old woman who was receiving AC during her pregnancy and lactating time for management of hypertension. The maternal plasma level and breast milk as well as c...
Acebutolol (AC) is a chiral b-adrenergic blocking drug, which is useful clinically as the racemate in treating hypertension and is metabolized to an equipotent chiral metabolite, diacetolol (DC). In this paper we report a case of a 32 year old woman who was receiving AC during her pregnancy and lactating time for management of hypertension. The maternal plasma level and breast milk as well as c...
OBJECTIVE To find out the effective anticancer drugs from bacterial products, petroleum ether extract of Corynebacterium xerosis. METHODS Antiproliferative activity of the metabolite has been measured by monitoring the parameters like tumor weight measurement, tumor cell growth inhibition in mice and survival time of tumor bearing mice, etc. Hepatoprotective effect of the metabolites was dete...
Atherosclerotic heart disease includes acute coronary syndromes and hyperlipidmia. The prescription of patients with atherosclerotic heart disease mostly contains atorvastatin and clopidogrel. Aim of this study is to estimate clinical pharmacokinetic interaction between atorvastatin and clopidogrel in atherosclerotic heart disease patients. This study was conducted by estimating the carboxylic ...
A recent traffic fatality has been attributed to the use of the drug methylenedioxymethamphetamine (MDMA). The deceased was a 29-year-old white male with no known history of drug abuse. Toxicological analysis detected MDMA and metabolite methylenedioxyamphetamine (MDA) in the blood, urine, and vitreous humor specimens submitted for analysis. The concentrations of MDMA in clotted blood, sodium f...
BACKGROUND Buprenorphine is a semi-synthetic opioid used for the treatment of opioid dependence. Opioid use, including buprenorphine, has been increasing in recent years, in the general population and in pregnant women. Consequently, there has been a rise in frequency of neonatal abstinence syndrome (NAS), associated with buprenorphine use during pregnancy. The purpose of this study was to inve...
Phosphorylation of xenobiotics is rare, probably owing to a strong evolutionary pressure against it. This rarity may have attracted more attention recently as a result of intentionally designed kinase-substrate analogs that depend on kinase-catalyzed activation to form phosphorylated active drugs. We report a rare phosphorylated metabolite observed unexpectedly in mouse plasma samples after an ...
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