BACKGROUND Studies on intracardiac echocardiography for transcatheter closure of secundum atrial septal defect (ASD) only include ASDs ≤38mm diameter without rim deficiency. AIMS To assess transcatheter closure of complex ASDs under intracardiac echocardiography guidance. METHODS Retrospective study from January 2006 to January 2012 in all consecutive adult patients referred to our centre f...

Adult spinal deformity (ASD) is a very diverse condition that affects the quality of life of the involved individuals deeply. There is an ongoing discussion as to whether treatment should be surgical (which is potentially dangerous) or non-surgical.In addition to a systematic review of literature on the surgical treatment of ASD with special emphasis on complications, a decision-analysis was pe...

We examined 2 hypotheses concerning the development of audience design by contrasting children with and without autistic spectrum disorder (ASD) in referential communication. The 2-stage hypothesis predicts that the ability to use contrastive size adjectives for ambiguity avoidance develops separately from and faster than the ability to avoid perspective-inappropriate descriptions for their add...

A 22-year-old man presented with his parents to the family physician owing to progressive withdrawal from family and avoidance of social or vocational opportunities. He reported depressed mood with diminishing motivation and energy and ruminative thoughts before falling asleep and after waking. There were no detectable medical contributors or substance abuse. He had always been reluctant to mak...

Despite increased awareness and concern about children with developmental disabilities wandering away from adult supervision, there is a paucity of research about elopement. This is the first study to examine and report the prevalence and correlates of elopement in a nationally representative sample of school-age children in the United States with an autism spectrum disorder (ASD) and/or cognit...

Insulin-like growth factor 1 (IGF-1) signaling promotes brain development and plasticity. Altered IGF-1 expression has been associated to autism spectrum disorders (ASD). IGF-1 levels were found increased in the blood and decreased in the cerebrospinal fluid of ASD children. Accordingly, IGF-1 treatment can rescue behavioral deficits in mouse models of ASD, and IGF-1 trials have been proposed f...

BACKGROUND CONTEXT Radiographic evaluation in adult spinal deformity (ASD) offers no information on spinopelvic alignment and compensation during dynamic conditions. Motion analysis the potential to bridge gap between static radiographic measurement, increasing our understanding how ASD impacts function. PURPOSE This study aimed explore changes sagittal strategies upright standing walking, comp...