Macro biomolecules are of vital importance in regulating the biofunctions organisms, which proteins (including peptides when mentioned below) and nucleic acids (NAs) most important. Therefore, these NAs can be applied as “drugs” to regulate from abnormal normal. Either for NAs, challenging thing is avoid biodegradation or physicochemical degradation before they reach targeted location, then fun...

Silver nanoparticles (AgNPs) are extensively used in various industries due to their unique physico-chemical and antimicrobial properties. Many natural biomolecules in plants (inactivated plant tissue, plant extracts and living plant) such as proteins/enzymes, amino acids, polysaccharides, alkaloids, alcoholic compounds, and vitamins could be involved in bioreduction, formation and stabilizatio...

A convenient synthesis of a novel heterobifunctional linker molecule is described. The linker contains a thiol-reactive nitropyridyl disulfide group (Npys) and an aldehyde-reactive aminooxy group with a propensity to form disulfide and oxime linkages. The utility of the linker molecule to cross-link different biomolecules has been demonstrated by employing it in the efficient preparation of a p...

Dynamic variations in the distances between pairs of atoms are used for clustering subdomains of biomolecules. We draw on a well-known target function for clustering and first show mathematically that the assignment of atoms to clusters has to be crisp, not fuzzy, as hitherto assumed. This reduces the computational load of clustering drastically, and we demonstrate results for several biomolecu...

In most contemporary life forms, the confinement of cell membranes provides localized concentration and protection for biomolecules, leading to efficient biochemical reactions. Similarly, confinement may have also played an important role for prebiotic compartmentalization in early life evolution when the cell membrane had not yet formed. It remains an open question how biochemical reactions de...