Overnight orthokeratology is becoming more and more popular especially in the Asia-Pacific region where the treatment is primarily used for myopic control in young children. Risk of complications in contact lens wear increases during overnight wear and may further increase when the treatment is used on children. The aim of this paper is to provide a comprehensive guideline for practitioners to ...

The conduct of clinical trials falls within a strict regulatory framework. The objective of the round table was to develop reasonable recommendations for the implementation of GCP according to the type of research and taking in account the risks and challenges related to this research. Two types of risks have been identified: those related to the characteristics of the research and those relate...

In this contribution we demonstrate how a Single Objective Genetic Programming (SOGP) and a Multi-Objective Genetic Programming (MOGP) algorithm can be used to evolve accurate input-output models of dynamic processes. Having described the algorithms, two case studies are used to compare their performance with that of Filter-Based Neural Networks (FBNNs). For the examples given, the models gener...

Central reading centers (CRCs) have several crucial roles in the conduct of clinical trials, providing key input during the study design, preparation of the operations manual, as well as site and photographer certification. They provide objective, standardized grading of images from study subjects, which determines study eligibility, and also evaluate lesion features at subsequent study visits....

Background and Objectives: Pre-requisite programs (PRPs) are “primary conditions and requirements essential for HACCP operations, which are crucial in food safety programs”. The present study was conducted to evaluate the impact of implementation of PRPs on the microbial parameters of pasteurized milk (according to the National Standard of Iran). Effectiveness of HACCP operation req...

Cellular manufacturing (CM) is one of the most important subfields in the design of manufacturing systems and as a recently emerged field of study and practice, virtual cellular manufacturing (VCM) inherits the importance from CM. One type of VCM problems is VCM with alternative processing routes from which the route for processing each part should be selected. In this research, a bi-objective ...