INTRODUCTION The mechanisms by which mechanical ventilation (MV) can injure remote organs, such as the kidney, remain poorly understood. We hypothesized that upregulation of systemic inflammation, as reflected by plasma interleukin-6 (IL-6) levels, in response to a lung-injurious ventilatory strategy, ultimately results in kidney dysfunction mediated by local endothelin-1 (ET-1) production and ...

OBJECTIVE To assess the effectiveness of a two year exercise programme of progressive balance retraining in reducing injurious falls among women aged 75-85 at increased risk of falls and injuries and living in the community. DESIGN Pragmatic multicentre, two arm, parallel group, randomised controlled trial. SETTING 20 study sites in 16 medium to large cities throughout France. PARTICIPANT...

A key area of concern in children with autism spectrum disorders (ASDs) are self-injurious behaviors (SIBs). These are behaviors that an individual engages in that may cause physical harm, such as head banging, or self-biting. SIBs are more common in children with ASD than those who are typically developing or have other neurodevelopmental disabilities. Therefore, it is important that clinician...

Background: Only 2% of falls in older adults result serious injuries (i.e., hip fracture). Therefore, it is important to differentiate injurious versus non-injurious falls, which critical develop effective interventions for injury prevention. Objects: The purpose this study was a. extract the best features surface electromyography (sEMG) classification and b. find a model provided by data minin...

Considered signs of decreased welfare--abnormal behaviors such as self-injury and self-abuse among nonhuman primates housed in the laboratory--may put into question the validity and reliability of scientific research using these animals as models. Providing environmental enrichment decreases the incidence of some undesirable behaviors but is often unsuccessful at ameliorating the most severe ty...

The effect of naltrexone (0.5, 1.0, 1.5, and 2.0 mg/kg) on the frequency of self-injurious behavior (SIB) was investigated in three male adolescents. The frequency of total SIB was reduced significantly in all three subjects; dose-dependent decreases (at 0.5, 1.0, and 1.5 mg/kg) in SIB frequency were observed in the two mentally retarded subjects. These data suggest a role for opioid peptides i...

conclusions the results confirm the available literature data, while noting that self-harming is a preponderantly male behavior. the results also signal the need to create opportunities to instruct teachers to combat the resistances and stereotypes of psychological distress. results data analysis confirms an association between self- cutting and alcohol use, sexual harassments, school dropout, ...

Mental health counselors are facing increased demand to treat both adolescents and adults who present with repetitive non-suicidal self-injurious behaviors, yet there are few empirically supported treatments or general treatment guidelines available. I will review the research on problem-solving and dialectical behavior therapy, two cognitive-behavioral treatments that have the most empirical s...