The effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) on cell cycle progression were examined in the human breast cell line MCF10A-Neo and a derivative line which expresses a Ha-ras oncogene (MCF10A-NeoT cells). Exposure of MCF10A-Neo cultures to TPA induced a G(1) arrest that lasted approximately 16-24 h (IC(50) approximately 0.5 nM). TPA-treated cultures produced a cytostatic conditioned ...

Two isoforms of estrogen receptor (ER) have been described: ERalpha and ERbeta. The initial gene targeting of ERalpha, consisting in the introduction of a Neo cassette in exon 1 [alphaERKO, hereafter called ERalpha-Neo KO (knockout)], was reported in 1993. More recently, another mouse deficient in ERalpha because of the deletion of exon 2 (ERalphaKO, hereafter called ERalpha-delta2 KO) was gene...

Rehabilitation robots have been demonstrated to be an efficient tool in the field of rehabilitation training. Meanwhile, there are varieties of tasks designed for motion training. These tasks need to be transmitted to motion data for rehabilitation robots. In this paper, we designed a drinking task and captured the motion data as the ground truth, through sensors of an exoskeleton device named ...

Five products of the dynorphin gene--alpha-neo-endorphin, beta-neo-endorphin, dynorphin A, dynorphin A-(1-8), and dynorphin B--were measured in various regions of rat brain and in rat spinal cord and pituitary. Specific antisera were used, supplemented by gel permeation analysis and high performance liquid chromatography, confirming the presence of dynorphin-32, dynorphin A, and dynorphin B in ...

The present study evaluated the latent structure of the NEO Five-Factor Inventory (NEO FFI) and relations between the five-factor model (FFM) of personality and dimensions of DSM-IV anxiety and depressive disorders (panic disorder, generalized anxiety disorder [GAD], obsessive-compulsive disorder, social phobia [SOC], major depressive disorder [MDD]) in a large sample of outpatients (N = 1,980)...

Neo-shamanism is a largely unexplored spiritual practice among Western peoples that, by virtue of its queerness, has pressing implications for archaeologists. In their practices, Druidic neo-shamans increasingly make pilgrimages to ancient sites and express strong views on the socio-politics of their presentation and management. Rather than avoid the ‘fringe’ and dismiss these engagements with ...

This study compared the balance between effort (E) and reward (R) among physicians and nurses working in pediatric (PED) and neonatal (NEO) Intensive Care Units. This descriptive cross-sectional study was carried out with 37 physicians and 20 nurses. The Effort-Reward Imbalance Questionnaire was used. Statistically significant differences were not found among physicians (p>0.05) or nurses from ...

In 2004 and 2005, Johnson et al. published two very provocative studies (1, 2), in which they claimed that in the adult mouse ovary, neo-oogenesis takes place and originates either from the ovarian surface epithelium (OSE) (1) or from the bone marrow (BM) via circulating blood cells (2). These studies were provocative since they challenged the long-held view that mammals are born with a finite ...

This paper brings together a number of empirical research results on novice programmers, using a neo-Piagetian theoretical framework. While there already exists literature connecting programming with classical Piagetian theory, in this paper we apply neo-Piagetian theory. Using that neo-Piagetian perspective, we offer an explanation as to why attempts to predict ability for programming via clas...

We have developed a new antimetastatic chemotherapeutic strategy for combination with hepatic resection of human colon cancers in a high-metastasis nude mouse model. The new procedure involves i.p. administration of 5-fluorouracil (5-FU) 2 h before hepatic resection of the human colon tumors, with therapy continued postoperatively for 4 consecutive days. We termed this strategy neo-neoadjuvant ...