December 22, 2016 Type Package Title Identification of mutational clusters in protein quaternary structures. Version 1.6.0 Date 2014-09-25 Author Gregory Ryslik, Yuwei Cheng, Hongyu Zhao Maintainer Gregory Ryslik Description Identifies clustering of somatic mutations in proteins over the entire quaternary structure. License GPL-2 biocViews Clustering, Proteomics, Somat...

The dual activation of acyl phosphonates and formaldehyde tert-butyl hydrazone by a BINAM-derived bis-urea catalyst is the key to achieve high reactivities and enantioselectivities in the synthesis of densely functionalized quaternary α-hydroxy phosphonates. Subsequent high-yielding transformations in a 'one-pot' fashion provide direct access to valuable azoxy compounds and quaternary α-aryl-ph...

February 1, 2017 Type Package Title Identification of mutational clusters in protein quaternary structures. Version 1.6.0 Date 2014-09-25 Author Gregory Ryslik, Yuwei Cheng, Hongyu Zhao Maintainer Gregory Ryslik Description Identifies clustering of somatic mutations in proteins over the entire quaternary structure. License GPL-2 biocViews Clustering, Proteomics, Somati...

Main-chain chiral quaternary ammonium polymers were successfully synthesized by the quaternization polymerization of cinchonidine dimer with dihalides. The polymerization occurred smoothly under optimized conditions to give novel type of main-chain chiral quaternary ammonium polymers. The catalytic activity of the polymeric chiral organocatalysts was investigated on the asymmetric benzylation o...

Hemoglobin is the prototypic allosteric protein. Still, its molecular allosteric mechanism is not fully understood. To elucidate the mechanism of cooperativity on an atomistic level, we developed a novel computational technique to analyse the coupling of tertiary and quaternary motions. From Molecular Dynamics simulations showing spontaneous quaternary transitions, we separated the transition t...

Two series of rosin quaternary ammonium salts (QAS) were synthesized using the same path. The structure of the target products was characterized by HPLC, MS, IR, and 1 HNMR, and the bioactivity was determined by filter paper method using Trametes versicolor (white-rot fungus) and Gloeophyllum trabeum (brown-rot fungus), which are two kinds of general wood decay fungi in nature. The results show...

A dianionic Ireland-Claisen rearrangement of chiral, nonracemic α-methyl-β-hydroxy allylic esters has been developed that proceeds with high diastereoselectivity and provides products containing three contiguous stereogenic carbons, including a quaternary center. The potential utility of the rearrangement for complex molecule synthesis is also demonstrated.

Depending on the spacing of their positive charges, ionenes, a class of quaternary ammonium polymers, increased the interferon-inducing activity of poly(inosinic acid).poly(cytidylic acid) in mouse L-929 cells, whereas they did not enhance poly(inosinic acid).poly(cytidylic acid) induced interferon production in primary rabbit kidney and human skin fibrolast cells.

Shedlovsky's results,16 which differ from all others. There can be no doubt that most if not all, of these minima are spurious. One observation, which we have made may have an important bearing on this problem. In many cases, on addition of the first sample, the resistance of the solution drifted to lower values. The rate of this drift depended on the salt as well. as on the sample. In some ins...

A silicogermanate, PKU-12, with the -CLO type of zeolite framework was hydrothermally synthesized under fluoride media using diisopropylethylmethylammonium as a structure directing agent. The formation of the silicogermanate zeolite with 20-ring channels has not only extended the -CLO family from phosphates into silicogermanates, but also demonstrated its structural diversity.