background: stem-cell technology has been advocated as a potentially curative option for treatment of both type 1 and type 2 diabetes. in the current study, we aimed to assess the effectiveness of allotransplantation of fetal liver-derived cells for treatment of patients with type 1 diabetes. methods: for the purpose of the current study, 72 patients with recently diagnosed type 1 dm were recru...

context connective tissue cells include fibroblasts, chondrocytes, adipocyte, and osteocytes. these cells are specialized for the secretion of collagenous extracellular matrix and are responsible for the architectural framework of the human body. evidence acquisition connective tissue cells play a central role in supporting as well as repairing tissues and organs. fibroblast cell therapy could ...

the first necessary step in researches to treat spinal cord injuries (sci) is to understand complexities related to the neurophysiology and neurobiology changes of human sci with stem cell therapy(sct). the aim of this study is to identify these changes. the level of injuries is important in treatment and determination of this injury (whether it is complete, incomplete, or discomplete) is valua...

it is estimated that annually 10 million people are affected by traumatic brain injury and it is one of the major causes of death and disability in accidents. studies have shown the potential therapeutic value of neural stem cell therapies. also, neural stem cell motility and migration to the site of injury has a great regeneration value of the damaged tissues. extracellular and intracellular f...

epilepsy is neurological disorders that afflict many people around the world with a higher prevalence rate in children and in low income countries. temporal lobe epilepsy (tle) is result from hippocampal sclerosis is a neurological disorder with difficult treatment. stem cells can transform into any type of cells such as glial cells, consequently stem cells can use for medical treatment. stem c...

this study was conducted to optimize a highly efficient mrna transfection into dendritic cells (dc) derived from esophageal squamous cell carcinoma (escc) patients. applying an electroporation technique, in vitro synthesized green fluorescent protein (gfp) mrna was transfected as an indicator into the dcs derived from a healthy donor. flow cytometry revealed 84.9% transfection efficiency for dc...

parkinson’s disease (pd) is the second most common neurodegenerative brain disorder which is around 1.5 times more common in men than in women. currently, drug medications, surgery, and lifestyle changes are common approaches to pd, while all of them focused on reducing the symptoms. therefore, regenerative medicine based on stem cell (sc) therapies has raised a promising hope. various types of...

background: antibiotic prophylaxis is usually used in allogenic stem cell transplantation, but its use in autologous stem cell transplantation (asct) is controversial. we evaluated the efficacy of ciprofloxacin prophylaxis in asct. materials and methods: to identify the efficacy of ciprofloxacin on the incidence of neutropenic fever and its complications, 72 patients had been admitted to talegh...

background: numerous in vitro reports suggest that low level laser therapy (lllt) affects cellular processes by biostimulation, however most of them emphasize on using visible light lasers which have low penetration. the aim of this study was to determine the effect of infrared laser light (which is more useful in clinic because of its higher penetration) on secretion of fibroblast growth facto...

cell based therapeutics is one of the most rapidly advancing medical fields, bringing together a range of fields including transplantation, tissue engineering and regeneration, biomaterials and stem cell biology. however, traditional cell-based therapeutics have many limitations, one of which is their harmful effects exhibited on healthy body cells due to their lack of specificity. nanomedicine...