To date, only a few studies on the azithromycin (AZM) pharmacokinetics in ornamental birds have been published. In current study AZM concentrations domestic pigeon (Columba livia domestica) plasma samples were analyzed using validated ultra-high performance liquid chromatography tandem mass spectrometry method. The aim of was to carry out an analysis and pharmacodynamics after administration si...

A remarkable non-linearity was found between dose and transfection activities of non-viral gene delivery systems, such as a Lipofectamine/DNA complex and an octaarginine-modified multifunctional envelope-type nano device (R8-MEND). We measured the nuclear delivery of pDNA to distinguish the non-linearity in intracellular pharmacokinetics or pharmacodynamics after transfection with R8-MEND at di...