t cell acute lymphoblastic leukemia (all) is an invasive disease with a higher incidence in children and adolescents. in terms of immunophenotype, t-all is positive for cd2, cd7, cd34 and hla-dr, and the level of these markers is increased with increasing age. in addition, the myeloid markers (cd13, cd33) are sometimes expressed in t-all. in this study, we introduce a rare case of a 28-year-old...

conclusions our findings indicated that mdm2 40-bp ins/del polymorphism was not associated with all in our iranian population. further studies with larger sample sizes and diverse ethnicities are required to verify our findings. background the human murine double minute 2 (mdm2), an oncoprotein, is the major negative regulator of p53. objectives the purpose of this study was to evaluate the imp...

T-cell acute lymphoblastic leukemia is an aggressive hematologic malignancy which is usuallyassociated with unfavorable prognosis particularly in patients with refractory/relapsed disease.Therefore, development of novel therapeutic strategies is highly required for improving theoutcome of these patients. Although there are several studies evaluating the efficacy of proteasome<...

Abnormalities of the thyroid gland are among the most frequent endocrine complications observed in childhood cancer survivors. We report an 11 years old girl who developed central hypothyroidism and ACTH deficiency during the chemotherapy for CNS relapse of acute lymphoblastic leukemia before receiving radiotherapy. Keywords: Thyroid gland, hypothyroidism, chemotherapy, acute lymphoblastic leu...

Sgc8c aptamers on a stiff polymer scaffold form multivalent inhibitor targeting acute lymphoblastic leukemia.

FACTORS EFFECTIVE IN THE PROGNOSIS OF NEUTROPENIC FEVER CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA

abstract background: high temperatures have destructive effects on cancer cells by damaging proteins and structures within cells. gold nanoparticles (aunps) can act as drug delivery vehicles, especially for cancer therapy. due to the selective intake of asparagine molecules into malignant cells, aunps were coated with asparagine; and ccrf-cem human t-cell leukemia cells were treated with the ne...

abstract background cancer diagnosis may cause deep emotional and affective problems in patients and their families.nowadays, however, despite its rising prevalence,cancer is no longer synonymous with death. given the significance of emotional well-being in cancer patients, we decided to assess the frequency of psychological problems in seven to seventeen yearolds with acute lymphoblastic leuke...