Prognosis of childhood acute lymphoblastic leukemia (ALL) has been dramatically improved. However, prognosis of the cases refractory to primary therapy is still poor. Recent phase 2 study on the efficacy of combination chemotherapy with bortezomib (BTZ), a proteasome inhibitor, for refractory childhood ALL demonstrated favorable clinical outcomes. However, septic death was observed in over 10% ...

The three dimensional black hole solutions of Bañados, Teitelboim and Zanelli (BTZ) are dimensionally reduced in various different ways. Solutions are obtained to the JackiwTeitelboim theory of two dimensional gravity for spinless BTZ black holes, and to a simple extension with a non-zero dilaton potential for black holes of fixed spin. Similar reductions are given for charged black holes. The ...

The purpose of this study was to determine the potential benefits of combination therapy using dimercaptosuccinic acid modified iron oxide (DMSA-Fe3O4) magnetic nanoparticles (MNPs) combined with nontoxic concentration of bortezomib (BTZ) and gambogic acid (GA) on multiple myeloma (MM) RPMI-8226 cells and possible underlying mechanisms. The effects of BTZ-GA-loaded MNP-Fe3O4 (BTZ-GA/MNPs) on ce...

Bis(benzotriazol-1-yl)phenylmethane CHPh(btz)2 and tris(benzotriazol-1-yl)methane CH(btz)3 were used as N-donor ligands to prepare luminescent heteroleptic copper(I) complexes. [Cu{CHPh(btz)2}(PPh3)2][BF4] [Cu{CHPh(btz)2}(DPEphos)][BF4] (DPEphos = bis[(2-diphenylphosphino)phenyl] ether) obtained from the corresponding borohydride complexes [Cu(BH4)(PPh3)2] [Cu(BH4)(DPEphos)] tetrafluoroboric ac...

INTRODUCTION Mantle cell lymphoma (MCL) is an incurable, often aggressive B-cell malignancy. Bortezomib (BTZ), the 20S proteasome inhibitor was originally developed and approved for treatment of relapsed refractory multiple myeloma, and subsequently approved for treatment of MCL. BTZ's single-agent activity induces clinical responses in approximately one-third of relapsed MCL patients. BTZ-cont...

Bortezomib (BTZ) is a reversible proteasome inhibitor. It affects NF-κB activity and has shown clinical efficacy in multiple myeloma. However, the same mechanisms through which it curtails malignant growth may compromise antitumor immunity. As dendritic cells (DC) play a vital role in the elicitation and maintenance of antitumor immunity, we studied the long-term effects of BTZ on human DC deve...

We study the dynamical behavior of the BTZ(Banados-Teitelboim-Zanelli) black hole with the low-energy string effective action. The perturbation analysis around the BTZ black hole reveals a mixing between the dilaton and other fields. Introducing the new gauge(dilaton gauge), we disentangle this mixing completely and obtain one decoupled dilaton equation. We obtain the decay rate Γ of BTZ balck ...

The T-cell lymphoproliferative neoplasms (T-LPN) are characterized by a poor clinical outcome. Current therapeutics are mostly non-selective and may induce harmful side effects. It has been reported that NOTCH1 activation mutations frequently associate T-LPN. Because anti-Notch1 based therapies such as γ-secretase inhibitors (GSI) are less efficient and induce considerable side effects, we hypo...

A novel CuBi2O4 consisting of self-assembled spherical nanocolumn arrays (CuB-H) was synthesized via a facile hydrothermal method. It was further modified by controlling the Cu:Bi ratio during synthesis to become an efficient bi-functional catalyst (CuB-2.5) activate persulfate (PS) and peroxymonosulfate (PMS) for 1H-benzotriazole (BTZ) removal. Characterization of CuB-2.5 using XRD, 10 FESEM, ...