with Community-Acquired Bacterial Pneumonia O. O. Okusanya1, S. M. Bhavnani1, A. Forrest1, C. C. Bulik1, B. Jamieson2, D. Oldach2, P. Fernandes2, P. G. Ambrose1 1Institute for Clinical Pharmacodynamics, Latham, NY; 2Cempra Pharmaceuticals, Chapel Hill, NC Abstract Materials and Methods Results Olanrewaju O. Okusanya, Pharm.D., M.S., BCPS Institute for Clinical Pharmacodynamics 43 British Americ...

Knowledge of the antimicrobial pharmacodynamic characteristics of a drug (inhibition of growth, rate and extent of bactericidal action, and postantibiotic effect) provides a more rational basis for determination of optimal dosing regimens in terms of the dose and the dosing interval. This article reviews concepts of antimicrobial pharmacodynamics, the effect of pharmacodynamics on the emergence...

Association of Fluconazole Pharmacodynamics with Mortality in Patients with Candidemia John W. Baddley,* Mukesh Patel, Sujata M. Bhavnani, Stephen A. Moser, and David R. Andes Department of Medicine, Division of Infectious Diseases, and Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama; Birmingham Veterans Administration Medical Center, Birmingham, Alabama; Insti...

PURPOSE Dabrafenib is a selective, potent ATP-competitive inhibitor of the BRAFV600-mutant kinase that has demonstrated efficacy in clinical trials. We report the rationale for dose selection in the first-in-human study of dabrafenib, including pharmacokinetics, tissue pharmacodynamics, 2[18F]fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) pharmacodynamics, and dose-response rel...

Pharmacokinetic and pharmacodynamics principles are fundamental to achieving the optimal response to antiretroviral drug therapy: successful antiretroviral therapy depends on attaining a therapeutic drug concentration that maximizes efficacy and minimizes toxicity.[1] Understanding drug interactions plays an important role for clinicians in providing effective and safe antiretroviral therapy. D...

Pharmacodynamics is commanding a greater role in the study of antibiotic efficacy and determination of dosing regimens. The simple measurement of serum, tissue, and body fluid antibiotic concentration do not provide sufficient information concerning the rate of pathogen killing at the site of any postantibiotic effects that may be occurring. This article discusses the pharmacokinetic and pharma...

Pharmacokinetic and pharmacodynamics principles are fundamental to achieving the optimal response to antiretroviral drug therapy: successful antiretroviral therapy depends on attaining a therapeutic drug concentration that maximizes efficacy and minimizes toxicity.[1] Understanding drug interactions plays an important role for clinicians in providing effective and safe antiretroviral therapy. D...