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BACKGROUND Reported prevalence, penetrance and expression of deleterious mutations in the mismatch repair (MMR) genes, MLH1, MSH2, MSH6 and PMS2, may reflect differences in the clinical criteria used to select families for DNA testing. The authors have previously reported that clinical criteria are not sensitive enough to identify MMR mutation carriers among incident colorectal cancer cases. ...
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background: factor viii administration to hemophilia a patients results in an immune response (inhibitor formation) which significantly complicates the therapy. the present study was performed to determine the prevalence of inhibitor development in hemophilia a patients receiving recombinant factor viii therapy. materials and methods: this was an observational descriptive study. clotting factor...
Received January 20, 2016; Revised March 3, 2016; Accepted Marc 2016. From theDepartment of Surgery, San Francisco General Hospital/Unive of California, San Francisco, San Francisco, CA (Knudson); the Departm of Surgery, Uniformed Services University Bethesda MD (Elster); Pentagon, Washington, DC (Woodson); and the American College of geons, Chicago IL (Kirk, Turner, Hoyt). Correspondence addre...
background: inhibitory antibody to exogenous factor viii (fviii) is a major complication of hemophilia treatment. this study was conducted to determine the prevalence of inhibitor antibody directed against fviii.methods: from may 2010 to may 2011, 52 patients with severe hemophilia a admitted in amirkola children’s hospital were evaluated. those who had abnormal mixing study, antibody against f...
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