BACKGROUND Left ventricular mass (LVM) is more closely associated with volume load than pressure load. We assessed whether part of the genetic heritability of LVM can be explained by stroke volume (SV) inheritance. METHODS Echocardiographic LVM, SV and peripheral resistance were measured in 527 families with at least two relatives from the HyperGEN study (51% African-American, 43% men, 44% ob...

Results Group I showed impaired exercise capacity compared to Group II (VO2max = 72.8 ± 3.5 vs. 103 ± 16%, p = 0.01). At rest, both groups showed normal systolic function. Majority of Group I patients have impaired RV diastolic function (82% vs. 33%, P = 0.004). During DSMRI, right ventricular stroke volume (RV-SV) increased in Group II but not in Group I (+13 ± 8 ml, 5 ± 8 ml, p < 0.001). In G...

Anterior gradient 2 (AGR2) is a gene predominantly expressed in mucus-secreting tissues or in endocrine cells. Its expression is drastically increased in tumors including prostate cancer. Here we investigated whether AGR2 transcript levels can be used as a biomarker to detect prostate cancer (PCa). Using a PCR-based approach, we could show that in addition to the wild-type (AGRwt long and short...

BACKGROUND The second best conduit for coronary artery bypass graft surgery (CABG) is unclear. We sought to determine if the use of a second arterial conduit, the radial artery (RA), would improve long-term survival after CABG using the left internal thoracic artery (LITA) and saphenous vein (SV). METHODS We compared the 14-year outcomes in propensity-matched patients undergoing isolated, pri...

HYPOTHESIS A splenic vein (SV)-inferior mesenteric vein (IMV) anastomosis reduces congestion of the stomach and spleen after pancreaticoduodenectomy with resection of the SV-mesenteric vein confluence but carries a risk of left-sided venous hypertension. DESIGN Comparative retrospective study. SETTING Department of Digestive Surgery and Transplantation, University of Strasbourg, Strasbourg,...

OBJECTIVE To determine whether right liver lobe volume (RV) and spleen size measured utilizing magnetic resonance (MR) imaging could identify the presence and severity of cirrhosis in patients with hepatitis B. METHODS Two hundred and five consecutive patients with clinically confirmed diagnosis of cirrhosis due to hepatitis B and 40 healthy control individuals were enrolled in this study and...

During acute altitude exposure tachycardia increases cardiac output (Q) thus preserving systemic O2 delivery. Within days of acclimatization, however, Q normalizes following an unexplained reduction in stroke volume (SV). To investigate whether the altitude-mediated reduction in plasma volume (PV) and hence central blood volume (CBV) is the underlying mechanism we increased/decreased CBV by mea...

The normal human left ventricular response to large variations in preload was studied in 12 young men. M-mode echocardiograms were recorded at supine rest and compared with studies obtained during head-down tilt (HDT) at 50 and during progressive lower body negative pressure (LBNP) to -40 mm Hg. During HDT, end-diastolic volume (EDV) increased 23% (p < 0.001), stroke volume (SV) increased 35% (...

This experiment studied the effect of a modest difference in diet structure value (SV) on milk conjugated linoleic acid (CLA) contents of cows fed diets supplemented with extruded linseed, in situations where the diets provided enough SV and therefore did not induce milk fat depression. Six lactating Holstein cows were used in a crossover design with two treatments ('SV 1.50' and 'SV 1.73') and...