objective critical illness polyneuropathy and myopathy (cipnm) is a major complication of severe critical illness. previous studies have suggested that many risk factors such as sepsis, multiorgan failure, and neuromuscular blocking agents play a role in cipnm pathogenesis. the aim of this study was to evaluate possible risk factors in the development of cipnm in a pediatric intensive care unit...

Critical illness myopathy is one of the causes for failure to wean from ventilator. Although associate factors of dyselectrolytemia is to be ruled out and other causes for failure to wean is to be ruled out before diagnosing critical illness myopathy. Several factors play role in development of this condition. Here we present a case report of a post partum patient where we had encountered failu...

Lactate measurement in the critically ill has been traditionally used to stratify patients with poor outcome. However, plasma lactate levels are the result of a finely tuned interplay of factors that affect the balance between its production and its clearance. When the oxygen supply does not match its consumption, organisms such as man who are forced to produce ATP for their integrity adapt in ...

Anaemia occurs frequently during critical illness. Recent studies have increased our understanding of how well critically ill patients tolerate anaemia. It is known that anaemia does not result simply from diagnostic and physical blood loss, but is multifactorial in origin. Recently, abnormalities in circulating red cell function have been described that are potentially relevant to efficient ox...

It is usually associated with or accompanied with a coma producing septic encephalopathy. The neuropathy is usually not apparent and may be noted only when the brain dysfunction is resolving. Patients usually have a protracted hospital course complicated by multi-organ failure and the systemic inflammatory response syndrome. Elevated serum glucose levels and reduced albumin is risk factors for ...

Critical illness in pregnancy increases maternal and fetal morbidity and mortality. The critical illness can be related to pregnancy per se, or can be secondary to a concurrent medical illness. Early identification and appropriate management results in good outcomes with a short ICU stay. Late identification and delayed therapy results in poor maternal & fetal outcomes with development of multi...

A 48-year-old man with necrotizing fasciitis, acute renal failure, and post-operative from multiple surgical debridement of bilateral lower extremities underwent polysomnography as part of a research protocol. The patient was undergoing mechanical ventilation and was receiving continuous infusion of sedatives and narcotics for comfort. Intravenous midazolam at 5 mg per hour and fentanyl at 75 m...