the properties relevant to pharmacokinetics and pharmacodynamics of four series of synthesized s-triazine derivatives have been studied by quantitative structure-retention relationship (qsrr) approach. the chromatographic behavior of these compounds was investigated by using reversed-phase high performance thin-layer chromatography (rp-hptlc). chromatographic retention (rm0) was correlated with...

The properties relevant to pharmacokinetics and pharmacodynamics of four series of synthesized s-triazine derivatives have been studied by Quantitative structure-retention relationship (QSRR) approach. The chromatographic behavior of these compounds was investigated by using reversed-phase high performance thin-layer chromatography (RP-HPTLC). Chromatographic retention (RM0) was correlated with...

Erythromycin was the first macolide discovered in 1952. In 1990s new macrolides including clarithromycin, azithromycin, and dirithromycin were introduced to the market. We provide a review of their structure, pharmacokinetics, mechanisms of action, and indications in dermatology.

Objective(s): Phenytoin is an antiepileptic drug that is used worldwide. The whole-body pharmacokinetics of this drug have been extensively studied using 11C-phenytoin in small animals. However, because of the limited production amounts that are presently available, clinical 11C-phenytoin PET studies to examine the pharmacokinetics of phenytoin in humans have not yet been performed. We aimed to...

pioglitazone belongs to the thiazolidinedione (tzd) class of antidiabetic agents, with proven efficacy in increasing insulin sensitivity and in the treatment of type 2 diabetes mellitus in humans. pioglitazone has been proposed as a potential feed additive to reduce insulin resistance and consequently some of the metabolic disorders in transition cows. this study was aimed at determining the...

pharmacokinetics of ceftriaxone was studied in buffalo calves (bubalus bubalis) after single intravenousand intramuscular administration of 10 mg/kg body weight. the drug concentrations in plasma samples weremeasured by high performance liquid chromatography with uv detection. following intravenousadministration, the drug was rapidly distributed (cpo: 106.5 ± 9.64 μg/ml; t1/2α: 0.09 ± 0.01 h; v...

many premature neonates suffer from apnea, and aminophylline is administrated for them. the objective of this study was to reveal pharmacokinetic (pk) parameters of theophylline in iranian premature neonates. premature neonates (68) who were admitted in the neonatal intensive care unit (nicu) of namazi, hafez, and zeinabieh hospitals were included in the study. all of them received 5 mg/kg amin...

Inhaled administration of polymyxin B is increasingly used to treat multi-drug resistant bacterial lung infections. However, the lack clinical data on pharmacokinetics inhaled makes drug dose design, efficacy assessment and safety a challenge. In this study, from intravenous injections were deconvoluted by an equal-step numerical deconvolution algorithm derive absorption rate in vivo. The was s...

background: the purpose of this study was to characterize the pharmacokinetic parameters of mycophenolic acid (mpa) in iranian kidney transplant patients. methods: plasma mpa concentration of mycophenolate mofetile (mmf) 1 gram two times a day was measured in 21 iranian kidney transplant recipients receiving treatment. patients who entered the study had been transplanted for more than 3 months ...

tramadol is a centrally acting analgesic drug extensively metabolized in animal species. its clinicalresponse is mainly due to the m1 metabolite, poorly produced in dogs. grapefruit-juice can inhibit themetabolism of different drugs in animals and humans. the aim of the present study was to evaluate thepharmacokinetics of tramadol and its major metabolites after co-administration of tramadol an...