Introduction: Cervical cancer is amongst the leading causes of death in females. According to World Cancer Statistics, global incidence cervical 6.5% and mortality related it 7.5%. The most effective way screen thus treat early stages achieved by screening patients with Papanicolaou (Pap) smear. Aim: To assess spectrum lesions Pap smears, classify them as per Bethesda System reporting Cytology ...

OBJECTIVE To assess the effect of bacterial vaginosis (BV) on the risk of high-grade squamous intraepithelial lesions (HSIL) among HIV-seropositive women. METHODS A hospital-based prospective cohort study of HIV-seropositive women was conducted in Johannesburg, South Africa from January 2005 to September 2009. Multivariate log-binomial and Poisson regressions were used to estimate prevalence ...

Persistence and eventual integration of high-risk HPV (hrHPV) into the cervical cell is crucial to the progression of cervical neoplasia and it would be beneficial to morphologically identify this transformation in routine surgical pathology practice. Increased p16(INK4a) (p16) expression is a downstream event following HPV E7 binding to pRB. A study was conducted to assess the correlation betw...

A 68-year-old woman was found to have a 20-mm superficial lesion at the dentate line (Fig. 1). Narrow band imaging (NBI) revealed a well-demarcated area with irregular intrapapillary capillary loops, similar to the findings seen in esophageal superficial squamous cell carcinoma [1]. Endoscopic biopsy revealed a high-grade squamous intraepithelial lesion (HSIL). After delineating the lesion unde...

BACKGROUND p16 (INK4a) (p16) is a well-recognized surrogate molecular marker for human papilloma virus (HPV) related squamous dysplasia. Our hypothesis is that the invasive interventions and related morbidities could be avoided by objective stratification of positive cytologic interpretations by p16 immunostaining of cell block sections of cytology specimens. MATERIALS AND METHODS Nuclear imm...

background: sex workers and hiv seropositive women are at high risk of abnormal cervical cytology. the objective of this study was to compare the cervical cytology among three groups of women: active sex workers, hiv-infected women, and general population in iran. methods: this was a cross-sectional study performed in hazrat zeinab, lavan clinics and drop in center (dic) in shiraz, iran. this s...

Recent literature data suggest that the high-risk human papillomaviruses (HR-HPVs) testing with several molecular techniques could be an alternative to cytology in the detection of cervical intraepithelial neoplasias of grade 2 or worse (CIN2+). However, any molecular techniques have its own limits and may give false negative results which must be clearly known before undertaking a primary HPV ...

Cervical cancer serves as a biologic and an epidemiologic model for anal carcinoma and its precursors. The current incidence of cervical cancer in the United States is approximately 8 cases per 100,000 people. The incidence of anal cancer in men who had sex with men (MSM) prior to the HIV epidemic was 35 per 100,000—an incidence rate similar to that of cervical cancer before routine Pap testing...

Aim. Cervical cancer is one of the most common female malignancy with high mortality rates in developing countries. Our purpose is to present cervical cytologic abnormalities and the detection rate of epithelial abnormalities by cervical cytology (CC). Method. A total of 8972 conventional pap smear tests collected between August 2010 and August 2012 from Çankırı State Hospital were retrospectiv...

Objective: The high number of smear tests has a workload on pathologists/cytopathologists, which raises the concern for quality diagnoses. application high-risk human papillomavirus (hr-HPV) analyses with PAP begun to contribute clinical practice. In this study, we aimed show effect hr-HPV analysis results via atypical squamous cell/squamous intraepithelial lesion (ASC/SIL) ratio standards. Mat...