BACKGROUND The ability of folic acid in the periconceptional period to prevent the occurrence of neural tube defects has stimulated tremendous interest in its effects on other health outcomes. Its possible effect on oral clefts has generated considerable debate. The purpose of this systematic review and meta-analysis was to assemble evidence on the role of folate in the aetiology of cleft lip w...

background: crohn’s disease is an inflammatory bowel disease that can affect any part of the gastrointestinal (gi) tract including the mouth. bowel symptoms are predominant. oral involvement may precede the gi symptoms. this case report presents a patient affected by crohn’s disease with oral onset. case presentation: we present a 30-year-old pregnant woman complaining of chronic, multiple, yel...

Background: One of the most common congenital malformations, with widespread racial and regional variation is an orofacial cleft. The occurrence attributed to array environmental genetic factors. Blood grouping Rh factor are genetically determined. Any possible association clefts them helps in planning interventional services. Methods: A case control observational study was conducted on 111 sam...

Children with nonsyndromic oral clefts and with the CATCH 22 syndrome (acronym for cardiac defects, abnormal faces, thymus hypoplasia, clefts, and hypocalcemia) display a range of language and learning disabilities, the neurofunctional bases of which are not yet understood. This review summarizes recent event-related brain potential (ERP) studies on central auditory processing in infants and ch...

OBJECTIVE To estimate the prevalence of oral clefts in Brazil categorized by etiology and geographical region. METHODS Case reports of oral cleft in newborns in the period 1975 - 1994 were included in the study. Data was collected using the morbidity certificates of the Hospital de Reabilitação de Anomalias Craniofaciais (Craniofacial Abnormalities Rehabilitation Hospital), Ministry of Health...

OBJECTIVE To determine if maternal use of snuff (containing high levels of nicotine, low levels of nitrosamines and no combustion products) is associated with an increased risk of oral cleft malformations in the infant and whether cessation of snuff use or smoking before the antenatal booking influences the risk. METHOD A population-based cohort study was conducted on all live born infants, r...

BACKGROUND Pregnancy registries for women taking anticonvulsant drugs have been developed to determine more efficiently the fetal risks of each drug. A total of 722 drug-exposed pregnancies are needed to identify a sevenfold increase in the rate of occurrence of a specific abnormality, such as spina bifida, with a frequency of 1 in 1,000. METHODS The infants with major malformations born to t...