1Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health (NIH), Bethesda, MD; 2Metabolism Branch and 3Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD; 4Gene Expression Core Facility, Vascular Medicine Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, MD; 5Laboratory of ...

Center for Infectious Disease Imaging, Department of Radiology and Imaging Sciences, National Institutes of Health (NIH), Bethesda, MD 20892, USA National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD 20892, USA National Library of Medicine, National Institutes of Health (NIH), Bethesda, MD 20892, USA Department of Radiology and Imaging Sciences...

Data have been collected from 47 centers in Europe and North America on the treatment with porcine factor VIII concentrate of 74 acute bleeding episodes in 65 patients with acquired hemophilia. The median initial anti-human factor VIII auto-antibody inhibitor level was 38 Bethesda unit (BU)/mL (range 1.2 to 1,024) whereas that against porcine was 1 BU/mL (range 0 to 15). The mean initial dose o...

Objective: Thyroid nodule is the most common disease of thyroid gland and closely associated with cancer. The gold standard method in diagnosis Fine Needle Aspiration Biopsy (FNAB). Although relationship between nodules containing microcalcification malignancy well known, there no consensus on relation macrocalcification to adequacy FNAB. In this study, it was aimed compare results FNAB without...

1 Philips Healthcare, Cleveland, OH, USA, 2 Molecular Imaging Program, NCI, NIH, Bethesda, MD, USA, 3 SAIC-Frederick, Frederick, MD, USA, 4 Philips Research North America, NY, USA; 5 Laboratory of Pathology, NCI, NIH, Bethesda, MD, USA; 6 Center for Interventional Oncology, NCI and Radiology and Imaging Sciences, Clinical Center, NIH, Bethesda, MD, USA; 7 Urologic Oncology Branch, NCI, NIH, Bet...

OBJECTIVES To assess the malignancy rates of thyroid nodules repeatedly classified as Bethesda category III on fine needle aspiration (FNA), and to suggest management guidelines for these lesions. METHODS This is a retrospective study that included 395 thyroid nodules categorized as Bethesda III undergone either surgery or ultrasound (US) follow-up. There were 67 nodules classified a second t...

PURPOSE Sporadic colorectal cancers with high-frequency microsatellite instability (MSI-H) are related to hypermethylation of mismatch repair (MMR) genes and a higher frequency of BRAF mutations than Lynch syndrome. We estimated the feasibility of hereditary colorectal cancer based on hMLH1 methylation and BRAF mutations. METHODS Between May 2005 and June 2011, we enrolled all 33 analyzed pat...

In the past there has been considerable variation in the way thyroid cytology was reported by pathologists. As the need for improving patient care increased to include more conservative surgical procedures for the management of thyroid lesions, there was a need for a standardized reporting format. This had to be reproducible and universal so that the implications of the reporting categories wer...

Introduction: Incidence rates of anal cancer have been rising worldwide in the last 20 years. Due to embryological, histological and immunohistochemical similarities between the anal canal and the cervix, routine screening with anal cytology for precursor lesions in high-risk groups has been adopted. Objective: To determine interobserver agreement for the diagnosis of anal neoplasia by anal cyt...