Rhabdomyosarcoma of the larynx is an extremely rare disease. To date of the literature has been described only about 70 cases of rhabdomyosarcoma of the larynx, including the adult population — 39 cases. There is very little information about the clinical presentation and course of rhabdomyosarcoma of the larynx. The article presents a review of the literature and our own observations of the di...

UNLABELLED Despite gains in survival, outcomes for patients with metastatic or recurrent rhabdomyosarcoma remain dismal. In a collaboration between the National Cancer Institute, Children's Oncology Group, and Broad Institute, we performed whole-genome, whole-exome, and transcriptome sequencing to characterize the landscape of somatic alterations in 147 tumor/normal pairs. Two genotypes are evi...

The association between antenatal diagnostic X-ray exposure and risk of rhabdomyosarcoma in children was assessed in a national case-control study of 319 rhabdomyosarcoma cases and 319 matched controls. Data were collected by telephone interviews of subjects' parents. Overall, an odds ratio (OR) of 1.9 [95% confidence interval (CI), 1.1-3.4] was found for any X-ray examination of the mother dur...

* To whom correspondence should be addressed: Wendy Kar Yee Ng Tel: (519) 639-9128 E-mail: [email protected] INTRODUCTION Soft tissue tumours are classified according to the tissue they appear as: such as muscle, fat, fibrous tissue, vessels and nerves. Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood and adolescence, and is a skeletal muscle tumour. It occurs in any anato...

We present a rare case of rhabdomyosarcoma of lip in a neonate with multiple lesions within the head and necksub site hitherto unreported in the medical literature. This case report also reviews the scant medical literature on neonatal rhabdomyosarcoma.

The growth of many soft tissue sarcomas is dependent on aberrant growth factor signaling, which promotes their proliferation and motility. With this in mind, we evaluated the effect of sorafenib, a receptor tyrosine kinase inhibitor, on cell growth and apoptosis in sarcoma cell lines of various histological subtypes. We found that sorafenib effectively inhibited cell proliferation in rhabdomyos...

Rhabdomyosarcomas of the parotid and submandibular glands have the histological appearance of a skeletal muscle tumor yet can be found in tissue with no striated muscular elements. We examine the potential cell-of-origin for rhabdomyosarcoma and whether salivary tumors represent primary malignancy or metastasis. We have previously established genetically engineered mouse models of rhabdomyosarc...

Rhabdomyosarcoma is an aggressive childhood malignancy, accounting for more than 50% of all soft-tissue sarcomas in children. Even with extensive therapy, the survival rate among alveolar rhabdomyosarcoma patients with advanced disease is only 20%. The receptor tyrosine kinase Epidermal Growth Factor Receptor (EGFR) has been found to be expressed and activated in human rhabdomyosarcomas. In thi...

Rhabdomyosarcoma is a heterogeneous disease both in presentation and histology. Improvements multimodality therapy resulted the improved overall survival for patients with low-risk intermediate-risk but not metastatic disease. We reviewed contrasted North American European practice patterns, though ultimately principles of staging, surgery, radiation therapy, chemotherapy are similar Children's...