The fatty acid synthase inhibitor cerulenin (50 to 100 micrograms/ml) inhibited production of the polyketide mycotoxins alternariol (AOH) and alternariol monomethyl ether (AME) by the mold Alternaria alternata. The results suggested that AOH synthesis was inhibited by a direct mechanism by cerulenin, whereas production of AME was probably limited by a shortage of the precursor AOH.

We report the draft genome sequence of Alternaria alternata ATCC 34957. This strain was previously reported to produce alternariol and alternariol monomethyl ether on weathered grain sorghum. The genome was sequenced with PacBio technology and assembled into 27 scaffolds with a total genome size of 33.5 Mb.

The investigation was carried out at the laboratory of Plant Pathology Department, SASRD, Nagaland University (NU), Medziphema Campus, Nagaland, India during year kharif (August-October, 2020) to evaluate antagonistic potentiality Trichoderma spp. (T. harzianum, T. asperellum and virens) against three diseases pigeonpea viz. Alternaria leaf spot (Alternaria alternata), Collar rot (Sclerotium ro...

We describe a case of a progressive subcutaneous Alternaria alternata infection in the hand of a patient with chronic lymphocytic leukemia (CLL). The diagnosis was based upon the examination of tissue biopsy and isolation of the etiologic agent in culture. The identity of the isolate was determined by phenotypic characteristics and by sequencing the ITS and D1/D2 regions of the rDNA. Despite co...

BACKGROUND The fungal allergen Alternaria alternata is implicated in severe asthma and rapid onset life-threatening exacerbations of disease. However, the mechanisms that underlie this severe pathogenicity remain unclear. OBJECTIVE We sought to investigate the mechanism whereby Alternaria was capable of initiating severe, rapid onset allergic inflammation. METHODS IL-33 levels were quantifi...

BACKGROUND The prevalence of allergic diseases has risen in the last decades. The objective of this study was to determine the common allergens in children via the skin prick test. METHODS This cross-sectional study recruited 313 allergic children (4 months to 18 years old) referred to the Asthma and Allergy Clinic of Children's Medical Center in Tehran. A questionnaire containing demographic...

Phytopathogenic micromycetes induce dangerous crop diseases. Traditionally, fungicides have been used to prevent these In recent years, environmentally friendly non-chemical methods for combating fungal infections developed. particular, ultraviolet (UV) treatment of various wavelengths, intensities and origins has shown be effective. this work, we analysed the effect diode low-intensity shortwa...

Alternaria species are mainly saprophytic fungi, but some are plant pathogens. Seven pathotypes of Alternaria alternata use secondary metabolites of host-specific toxins as pathogenicity factors. These toxins kill host cells prior to colonization. Genes associated with toxin synthesis reside on conditionally dispensable chromosomes, supporting the notion that pathogenicity might have been acqui...

Sensitivity to fungi is a major risk factor for the development of asthma. However, the prevalence of fungal sensitivity in asthma is not completely understood. Nonetheless upward of 80% of asthmatic patients may be sensitized to one or more fungi. Fungal exposure occurs primarily from outdoors sources, but can occur in the indoor environment as well. Assessment of fungal exposure requires a mu...