BACKGROUND In Germany, clinical trials and comparative effectiveness studies in primary care are still very rare, while their usefulness has been recognised in many other countries. A network of researchers from German academic general practice has explored the reasons for this discrepancy. METHODS Based on a comprehensive literature review and expert group discussions, problem analyses as we...

In Recent times, pharmaceutical companies are faced with the demanding tasks such as adjustments to the unstable and turbulent market in times of economic crisis as well as to meet the customer needs. The pharmaceutical industry, manufacturing in a current Good manufacturing practice (cGMP) environment has been slow to adopt the lean manufacturing unlike many sectors where it has been successfu...