Blood-mediated nanoparticle delivery is a new and growing field in the development of therapeutics and diagnostics. Nanoparticle properties such as size, shape and surface chemistry can be controlled to improve their performance in biological systems. This enables modulation of immune system interactions, blood clearance profile and interaction with target cells, thereby aiding effective delive...

BACKGROUND In medicine, there is limited knowledge on the toxicity of nanoparticles. In medicine, there has been limited knowledge on the effect of nanoparticles on the white blood cell. OBJECTIVE To evaluate the effect of gold nanoparticle on the microscopic morphology of white blood cell. SETTING Chulalongkorn Univesity, Bangkok, Thailand. METHOD This study was performed as an experimen...

The development of targeted vehicles for systemic drug delivery relies on optimizing both the cell-targeting ligand and the physicochemical characteristics of the nanoparticle carrier. A versatile platform based on modification of gold nanoparticles with thiolated polymers is presented in which design parameters can be varied independently and systematically. Nanoparticle formulations of varyin...

Colorectal cancer has been one of the most common cancers in the worldwide. Poor patient compliance and serious side effects often associated with conventional therapy (e.g. surgery, radiation, and chemotherapy). Gene therapy may be an alternative strategy. Herein, we developed a dual-targeting nanoparticle with excellent gene transfection efficiency for gene therapy of peritoneal metastasis of...

Nonlinear thermo-optical properties of two-layered spherical system of gold nanoparticle core and water vapor shell, created under laser heating of nanoparticle in water, were theoretically investigated. Vapor shell expansion leads to decreasing up to one to two orders of magnitude in comparison with initial values of scattering and extinction of the radiation with wavelengths 532 and 633 nm by...

The results of the effects of electrolyte type and concentration, nanoparticle concentration, pH, and temperature on the mobility and aqueous stability of polyethylene glycol (PEG)-coated silica nanoparticles are presented. Nanoparticle mobility was evaluated based on the ability to inhibit montmorillonite swelling in aqueous solutions through visual swelling tests, and the results were quantif...

Molecular dynamics simulations were used to characterize the structure and dynamics for several peptides and the effect of conjugating them to a gold nanoparticle. Peptide structure and dynamics were compared for two cases: unbound peptides in water, and peptides bound to the gold nanoparticle surface in water. The results show that conjugating the peptides to the gold nanoparticle usually decr...

We study heat transfer from a heated nanoparticle into surrounding fluid using molecular dynamics simulations. We show that the fluid next to the nanoparticle can be heated well above its boiling point without a phase change. Under increasing nanoparticle temperature, the heat flux saturates, which is in sharp contrast with the case of flat interfaces, where a critical heat flux is observed fol...

We describe the synthesis and characterization of high-performance, superparamagnetic, iron oxide nanoparticle-based, heavy metal sorbents, which demonstrate excellent affinity for the separation of heavy metals in contaminated water systems (i.e., spiked Columbia River water). The magnetic nanoparticle sorbents were prepared from an easy-to-synthesize iron oxide precursor, followed by a simple...

genetic algorithm and partial least square (ga-pls), the kernel pls (kpls) and levenberg-marquardt artificial neural network (l-m ann) techniques were used to investigate the correlationbetween retention time (rt) and descriptors for 15 nanoparticle compounds which obtained by thecomprehensive two dimensional gas chromatography system (gc x gc). application of thedodecanethiol monolayer-protect...