Cleft lip and palate is the most frequent congenital oral dysmophosis (1/600 births). They can be associated with polyformative syndromes. The aetiology often unknown, but heredity still a predominant factor. These clefts result from an absence or insufficient fusion of different facial buds occurring fifth to 7th week intrauterine life. have several forms. treatment cleft requires multidiscipl...

In this report, we have reanalyzed genotyping data in a collection of families from South America based on maternal origin. Genotyping analysis was performed at the Craniofacial Anomalies Research Center at the University of Iowa. These genotypes were derived from genomic DNA samples obtained from blood spots from children born with isolated orofacial clefts in 45 hospitals located in eight cou...

OBJECTIVES First, to determine the infant mortality rate (IMR) for Dutch patients with isolated oral clefts (OC) as well as for patients with clefts seen in association with other malformations. Second, to conduct a similar analysis per cleft type: cleft lip with or without cleft palate (CP), CP (including Robin sequence). Third, to examine the underlying causes of death. MATERIAL AND METHODS...

This hospital-based, case-control study investigated the possible associations between family history of malformations, parental consanguinity, smoking and alcohol drinking and nonsyndromic orofacial cleft (OC, subdivided in 2 main groups: CL/P - cleft lip with or without cleft palate and CP - cleft palate alone). 274 cases were matched (age, sex and place of residence) to 548 controls. Odds ra...

OBJECTIVE To assess the efficacy of decellularized dermal grafting used as an adjunct to the performance of primary repair of wide cleft palates. DESIGN Retrospective review. SETTING Tertiary referral center for large managed care organization. METHODS Seven consecutive patients with clefts of the hard and soft palates wider than 15 mm as measured at the posterior edge of the hard palate....

This study was designed to obtain and compare the nasalance scores produced by normal Malay children and those with repaired palatal cleft. Data from 103 noncleft children and 27 children with repaired clefts were included. All children were of Malay origin with the Malay language (Kelantan dialect) as their first language. Two short and simple test stimuli were constructed in the Malay languag...

Oral clefts include cleft lip (CL), cleft palate (CP), and cleft lip and palate (CLP) and collectively these constitute a heterogeneous group of nonfatal birth defects known to be multifactorial in origin, in that both genes and environmental factors contribute to their etiology (Mitchell et al., ’02). The incidence of oral clefting varies from 0.6 to 1.7 per 1,000 Caucasian births. African Ame...

introduction: tessier facial cleft is among the rarest facial clefts reported in literatures and there are many issues arguing about its multidisciplinary repairing techniques. tessier number 4 and 5 are extremely rare facial anomalies. there are few literatures describing these clefts and their surgical modalities. number 5 tessier cleft begins medial to oral commissure in the upper lip and ex...