BACKGROUND Commensal as well as pathogenic bacteria can influence a variety of gut functions, thereby leading to constipation and diarrhea in severe cases. In fact, several researchers have reported evidence supporting the association between stool consistency or constipation and the Gut microbiome (GM) composition and dysbiosis. GM influences the human health and disease via the gut-brain axis...

BACKGROUND The present study examined pain perception in children and adolescents with ADHD and the interaction between pain perception and the administration of methylphenidate (MPH) in order to generate hypotheses for further research that will help to clarify the association between ADHD diagnosis, MPH treatment and pain perception. METHODS We included 260 children and adolescents of the "...

The perception of pain is highly variable. It depends on bottom-up-mediated factors like stimulus intensity and top-down-mediated factors like expectations. In the brain, pain is associated with a complex pattern of neuronal responses including evoked potentials and induced responses at alpha and gamma frequencies. Although they all covary with stimulus intensity and pain perception, responses ...

Placebo exhibits beneficial effects on pain perception in human experimental studies. Most of these studies demonstrate that placebo significantly decreased neural activities in pain modulatory brain regions and pain-evoked potentials. This study examined placebo analgesia-related effects on spontaneous brain oscillations. We examined placebo effects on four order-fixed 20-min conditions in two...

aim and background: it has since long been known that there is strong relation between   psychological status and functional gastrointestinal disorders (fgid). however, until recently, the nature of this putative relationship was unclear due to a lack of non-invasive methods to investigate the neurobiological mechanisms underlying this relationship.  functional brain imaging has provided a meth...

Background and Aim: Local anesthetic injection is among the most anxiety-provoking procedures in children. Some scales are currently available to quantify the level of pain experienced based on the child’s behavior. The purpose of this study was to compare two commonly used pain scales. Materials and Methods: This split-mouth study was conducted on 49 healthy children aged 3.5 to 9 years who n...